Treatment of obesity

Bruce Wolfe, Elizaveta Kvach, Robert H. Eckel

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

This review focuses on the mechanisms underlying, and indications for, bariatric surgery in the reduction of cardiovascular disease (CVD), as well as other expected benefits of this intervention. The fundamental basis for bariatric surgery for the purpose of accomplishing weight loss is the determination that severe obesity is a disease associated with multiple adverse effects on health, which can be reversed or improved by successful weight loss in patients who have been unable to sustain weight loss by nonsurgical means. An explanation of possible indications for weight loss surgery as well as specific bariatric surgical procedures is presented, along with review of the safety literature of such procedures. Procedures that are less invasive or those that involve less gastrointestinal rearrangement accomplish considerably less weight loss but have substantially lower perioperative and longer-term risk. The ultimate benefit of weight reduction relates to the reduction of the comorbidities, quality of life, and all-cause mortality. With weight loss being the underlying justification for bariatric surgery in ameliorating CVD risk, current evidence-based research is discussed concerning body fat distribution, dyslipidemia, hypertension, diabetes mellitus, inflammation, obstructive sleep apnea, and others. The rationale for bariatric surgery reducing CVD events is discussed and juxtaposed with impacts on all-cause mortalities. Given the improvement of established obesity-related CVD risk factors after weight loss, it is reasonable to expect a reduction of CVD events and related mortality after weight loss in populations with obesity. The quality of the current evidence is reviewed, and future research opportunities and summaries are stated.

Original languageEnglish (US)
Pages (from-to)1844-1855
Number of pages12
JournalCirculation Research
Volume118
Issue number11
DOIs
StatePublished - May 27 2016

Fingerprint

Weight Loss
Obesity
Bariatric Surgery
Cardiovascular Diseases
Therapeutics
Mortality
Body Fat Distribution
Morbid Obesity
Obstructive Sleep Apnea
Dyslipidemias
Comorbidity
Diabetes Mellitus
Quality of Life
Hypertension
Inflammation
Safety
Health
Research
Population

Keywords

  • cardiac metabolism
  • hypertension
  • inflammation
  • obesity
  • sleep apnea

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Treatment of obesity. / Wolfe, Bruce; Kvach, Elizaveta; Eckel, Robert H.

In: Circulation Research, Vol. 118, No. 11, 27.05.2016, p. 1844-1855.

Research output: Contribution to journalReview article

Wolfe, B, Kvach, E & Eckel, RH 2016, 'Treatment of obesity', Circulation Research, vol. 118, no. 11, pp. 1844-1855. https://doi.org/10.1161/CIRCRESAHA.116.307591
Wolfe, Bruce ; Kvach, Elizaveta ; Eckel, Robert H. / Treatment of obesity. In: Circulation Research. 2016 ; Vol. 118, No. 11. pp. 1844-1855.
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