Treatment of metastatic uveal melanoma

Review and recommendations

Daniel Albert, Arysol Soltero Niffenegger, James K.V. Willson

Research output: Contribution to journalReview article

109 Citations (Scopus)

Abstract

This article reviews the published clinical responses of metastatic uveal melanoma and metastatic cutaneous melanoma with visceral involvement to current therapeutic protocols. Despite isolated patient responses to systemic treatment, no effective treatment currently exists for metastatic uveal melanoma. However, several new approaches involving interferons and interleukin and combination chemotherapy have shown some activity against metastatic cutaneous melanoma. The effectiveness against metastatic uveal melanomas has not been determined. A new approach to intrahepatic administration of chemotherapy also warrants further evaluation because of the high incidence of hepatic involvement with metastatic uveal melanoma. When an effective systemic treatment is found, early administration as an adjuvant to primary treatment may provide the best strategy for control of systemic spread.

Original languageEnglish (US)
Pages (from-to)429-438
Number of pages10
JournalSurvey of Ophthalmology
Volume36
Issue number6
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Melanoma
Therapeutics
Skin
Interleukins
Combination Drug Therapy
Interferons
Uveal melanoma
Drug Therapy
Liver
Incidence

Keywords

  • chemotherapy
  • cutaneous melanoma
  • immunotherapy
  • malignant melanoma
  • uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Treatment of metastatic uveal melanoma : Review and recommendations. / Albert, Daniel; Niffenegger, Arysol Soltero; Willson, James K.V.

In: Survey of Ophthalmology, Vol. 36, No. 6, 01.01.1992, p. 429-438.

Research output: Contribution to journalReview article

Albert, Daniel ; Niffenegger, Arysol Soltero ; Willson, James K.V. / Treatment of metastatic uveal melanoma : Review and recommendations. In: Survey of Ophthalmology. 1992 ; Vol. 36, No. 6. pp. 429-438.
@article{5c637a70dade40d6bce8a5cb1a466194,
title = "Treatment of metastatic uveal melanoma: Review and recommendations",
abstract = "This article reviews the published clinical responses of metastatic uveal melanoma and metastatic cutaneous melanoma with visceral involvement to current therapeutic protocols. Despite isolated patient responses to systemic treatment, no effective treatment currently exists for metastatic uveal melanoma. However, several new approaches involving interferons and interleukin and combination chemotherapy have shown some activity against metastatic cutaneous melanoma. The effectiveness against metastatic uveal melanomas has not been determined. A new approach to intrahepatic administration of chemotherapy also warrants further evaluation because of the high incidence of hepatic involvement with metastatic uveal melanoma. When an effective systemic treatment is found, early administration as an adjuvant to primary treatment may provide the best strategy for control of systemic spread.",
keywords = "chemotherapy, cutaneous melanoma, immunotherapy, malignant melanoma, uveal melanoma",
author = "Daniel Albert and Niffenegger, {Arysol Soltero} and Willson, {James K.V.}",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/S0039-6257(05)80024-4",
language = "English (US)",
volume = "36",
pages = "429--438",
journal = "Survey of Ophthalmology",
issn = "0039-6257",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Treatment of metastatic uveal melanoma

T2 - Review and recommendations

AU - Albert, Daniel

AU - Niffenegger, Arysol Soltero

AU - Willson, James K.V.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - This article reviews the published clinical responses of metastatic uveal melanoma and metastatic cutaneous melanoma with visceral involvement to current therapeutic protocols. Despite isolated patient responses to systemic treatment, no effective treatment currently exists for metastatic uveal melanoma. However, several new approaches involving interferons and interleukin and combination chemotherapy have shown some activity against metastatic cutaneous melanoma. The effectiveness against metastatic uveal melanomas has not been determined. A new approach to intrahepatic administration of chemotherapy also warrants further evaluation because of the high incidence of hepatic involvement with metastatic uveal melanoma. When an effective systemic treatment is found, early administration as an adjuvant to primary treatment may provide the best strategy for control of systemic spread.

AB - This article reviews the published clinical responses of metastatic uveal melanoma and metastatic cutaneous melanoma with visceral involvement to current therapeutic protocols. Despite isolated patient responses to systemic treatment, no effective treatment currently exists for metastatic uveal melanoma. However, several new approaches involving interferons and interleukin and combination chemotherapy have shown some activity against metastatic cutaneous melanoma. The effectiveness against metastatic uveal melanomas has not been determined. A new approach to intrahepatic administration of chemotherapy also warrants further evaluation because of the high incidence of hepatic involvement with metastatic uveal melanoma. When an effective systemic treatment is found, early administration as an adjuvant to primary treatment may provide the best strategy for control of systemic spread.

KW - chemotherapy

KW - cutaneous melanoma

KW - immunotherapy

KW - malignant melanoma

KW - uveal melanoma

UR - http://www.scopus.com/inward/record.url?scp=0026749030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026749030&partnerID=8YFLogxK

U2 - 10.1016/S0039-6257(05)80024-4

DO - 10.1016/S0039-6257(05)80024-4

M3 - Review article

VL - 36

SP - 429

EP - 438

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

SN - 0039-6257

IS - 6

ER -