Treatment of Epilepsy in the Elderly

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The treatment of epilepsy in older individuals is an increasingly important topic in neurology and an area that all treating neurologists should have familiarity with. As the population ages, the number of patients over 65 who present with new-onset epilepsy will increase, as will the complexity of their comorbid medical and neurological disorders. In older patients, seizures are often unwitnessed, or present with atypical symptoms, making the diagnosis more challenging. Additionally, there are relatively limited data to guide the use of anti-epileptic medications and other treatments in this patient population. Elderly patients may experience increased side effects from anti-epileptic drugs compared with younger patients and in general, are likely to have a narrower therapeutic window and greater degree of individual variation with respect to side effects. Familiarity with anti-epileptic medication dosing and titration schedules, possible adverse effects, and potential pharmacokinetic and drug interactions can be helpful when considering treatment options and may increase the likelihood of success.

Original languageEnglish (US)
Article number96
JournalCurrent Neurology and Neuroscience Reports
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Epilepsy
Therapeutics
Neurology
Nervous System Diseases
Drug Interactions
Population
Appointments and Schedules
Seizures
Pharmacokinetics
Pharmaceutical Preparations
Recognition (Psychology)

Keywords

  • Anti-epileptic medication
  • Elderly
  • Epilepsy
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Treatment of Epilepsy in the Elderly. / Motika, Paul; Spencer, David.

In: Current Neurology and Neuroscience Reports, Vol. 16, No. 11, 96, 01.11.2016.

Research output: Contribution to journalReview article

@article{c7172459159041b8b2b8b31dcd4e2c68,
title = "Treatment of Epilepsy in the Elderly",
abstract = "The treatment of epilepsy in older individuals is an increasingly important topic in neurology and an area that all treating neurologists should have familiarity with. As the population ages, the number of patients over 65 who present with new-onset epilepsy will increase, as will the complexity of their comorbid medical and neurological disorders. In older patients, seizures are often unwitnessed, or present with atypical symptoms, making the diagnosis more challenging. Additionally, there are relatively limited data to guide the use of anti-epileptic medications and other treatments in this patient population. Elderly patients may experience increased side effects from anti-epileptic drugs compared with younger patients and in general, are likely to have a narrower therapeutic window and greater degree of individual variation with respect to side effects. Familiarity with anti-epileptic medication dosing and titration schedules, possible adverse effects, and potential pharmacokinetic and drug interactions can be helpful when considering treatment options and may increase the likelihood of success.",
keywords = "Anti-epileptic medication, Elderly, Epilepsy, Seizures",
author = "Paul Motika and David Spencer",
year = "2016",
month = "11",
day = "1",
doi = "10.1007/s11910-016-0696-8",
language = "English (US)",
volume = "16",
journal = "Current Neurology and Neuroscience Reports",
issn = "1528-4042",
publisher = "Current Medicine Group",
number = "11",

}

TY - JOUR

T1 - Treatment of Epilepsy in the Elderly

AU - Motika, Paul

AU - Spencer, David

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The treatment of epilepsy in older individuals is an increasingly important topic in neurology and an area that all treating neurologists should have familiarity with. As the population ages, the number of patients over 65 who present with new-onset epilepsy will increase, as will the complexity of their comorbid medical and neurological disorders. In older patients, seizures are often unwitnessed, or present with atypical symptoms, making the diagnosis more challenging. Additionally, there are relatively limited data to guide the use of anti-epileptic medications and other treatments in this patient population. Elderly patients may experience increased side effects from anti-epileptic drugs compared with younger patients and in general, are likely to have a narrower therapeutic window and greater degree of individual variation with respect to side effects. Familiarity with anti-epileptic medication dosing and titration schedules, possible adverse effects, and potential pharmacokinetic and drug interactions can be helpful when considering treatment options and may increase the likelihood of success.

AB - The treatment of epilepsy in older individuals is an increasingly important topic in neurology and an area that all treating neurologists should have familiarity with. As the population ages, the number of patients over 65 who present with new-onset epilepsy will increase, as will the complexity of their comorbid medical and neurological disorders. In older patients, seizures are often unwitnessed, or present with atypical symptoms, making the diagnosis more challenging. Additionally, there are relatively limited data to guide the use of anti-epileptic medications and other treatments in this patient population. Elderly patients may experience increased side effects from anti-epileptic drugs compared with younger patients and in general, are likely to have a narrower therapeutic window and greater degree of individual variation with respect to side effects. Familiarity with anti-epileptic medication dosing and titration schedules, possible adverse effects, and potential pharmacokinetic and drug interactions can be helpful when considering treatment options and may increase the likelihood of success.

KW - Anti-epileptic medication

KW - Elderly

KW - Epilepsy

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=84987892442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84987892442&partnerID=8YFLogxK

U2 - 10.1007/s11910-016-0696-8

DO - 10.1007/s11910-016-0696-8

M3 - Review article

C2 - 27628963

AN - SCOPUS:84987892442

VL - 16

JO - Current Neurology and Neuroscience Reports

JF - Current Neurology and Neuroscience Reports

SN - 1528-4042

IS - 11

M1 - 96

ER -