Treatment for BK virus: Incidence, risk factors and outcomes for kidney transplant recipients in the United States

Jesse D. Schold, Shehzad Rehman, Liise K. Kayler, Joseph Magliocca, Titte R. Srinivas, Herwig Ulf Meier-Kriesche

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

There has been a notable rise of BK virus among kidney transplant recipients. Single-center reports have identified risk factors for development of BK virus. However, there has not been an assessment of risk factors and incidence of this complication at a national level. This study utilized newly collected follow-up information from the national SRTR database to investigate incidence, risk factors and outcomes for solitary kidney transplant recipients associated with treatment for BK virus (TBKV) from 2004 to 2006. Logistic and Cox models were utilized to assess risk factors and evaluate graft survival associated with TBKV. Incidence of TBKV was 1.6% at 6 months and 2.6% at 1 year following transplantation. Patients with and without TBKV at 6 months had 79% and 90% 3-year overall graft survival respectively. Risk factors included advanced donor age, pediatric, African American and male recipients, human leukocyte antigen-mismatching and tacrolimus and thymoglobulin induction as baseline immunosuppression. Acute rejection episodes were more frequent prior to and following TBKV. TBKV is a common and rising incidence, varies based on transplant characteristics and should be included as a safety endpoint in studies investigating immunosuppressive protocols. Careful monitoring and further understanding of disease etiology and treatment strategies are needed.

Original languageEnglish (US)
Pages (from-to)626-634
Number of pages9
JournalTransplant International
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

BK Virus
Kidney
Incidence
Graft Survival
Therapeutics
Transplant Recipients
Tacrolimus
Immunosuppressive Agents
HLA Antigens
Proportional Hazards Models
African Americans
Immunosuppression
Transplantation
Logistic Models
Tissue Donors
Databases
Pediatrics
Transplants
Safety

Keywords

  • BK virus nephropathy
  • Graft survival
  • Kidney transplantation
  • Polyoma virus
  • Post-transplant complications

ASJC Scopus subject areas

  • Transplantation

Cite this

Treatment for BK virus : Incidence, risk factors and outcomes for kidney transplant recipients in the United States. / Schold, Jesse D.; Rehman, Shehzad; Kayler, Liise K.; Magliocca, Joseph; Srinivas, Titte R.; Meier-Kriesche, Herwig Ulf.

In: Transplant International, Vol. 22, No. 6, 01.06.2009, p. 626-634.

Research output: Contribution to journalArticle

Schold, Jesse D. ; Rehman, Shehzad ; Kayler, Liise K. ; Magliocca, Joseph ; Srinivas, Titte R. ; Meier-Kriesche, Herwig Ulf. / Treatment for BK virus : Incidence, risk factors and outcomes for kidney transplant recipients in the United States. In: Transplant International. 2009 ; Vol. 22, No. 6. pp. 626-634.
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