Traumatic brain injury and its effect on coagulopathy

Sean P. McCully, Martin Schreiber

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Polytraumatic injury results in tissue factor (TF) release from damaged cells. The acute coagulopathy of trauma (ACT) occurs early and results from significant tissue injury and tissue hypoperfusion. ACT is augmented by therapies resulting in acidemia, hypothermia, and hemodilution contributing to trauma-induced coagulopathy. Coagulopathy associated with traumatic brain injury (TBI) results from the interplay of numerous variables. Because of the high concentration of TF in brain tissue, TBI has been believed to be associated with a greater degree of coagulopathy compared with injury in other body systems. TBI has also recently been shown to cause platelet dysfunction. Platelet receptor inhibition prevents cellular initiation and amplification of the clotting cascade, limiting thrombin incorporation, and stabilization of clot to stop hemorrhage. Therefore, head injury in the presence of polytrauma does appear to augment ACT and warrants close monitoring and appropriate intervention.

    Original languageEnglish (US)
    Pages (from-to)896-901
    Number of pages6
    JournalSeminars in Thrombosis and Hemostasis
    Volume39
    Issue number8
    DOIs
    StatePublished - 2013

    Fingerprint

    Wounds and Injuries
    Thromboplastin
    Blood Platelets
    Hemodilution
    Multiple Trauma
    Traumatic Brain Injury
    Hypothermia
    Craniocerebral Trauma
    Thrombin
    Hemorrhage
    Brain
    Therapeutics

    Keywords

    • coagulopathy
    • hemostasis
    • trauma
    • traumatic brain injury

    ASJC Scopus subject areas

    • Hematology
    • Cardiology and Cardiovascular Medicine

    Cite this

    Traumatic brain injury and its effect on coagulopathy. / McCully, Sean P.; Schreiber, Martin.

    In: Seminars in Thrombosis and Hemostasis, Vol. 39, No. 8, 2013, p. 896-901.

    Research output: Contribution to journalArticle

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