Translational in vivo models for women’s health: The nonhuman primate endometrium—a predictive model for assessing steroid receptor modulators

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Scopus citations

    Abstract

    Macaques and baboons display physiological responses to steroid hormones that are similar to those of women. Herein, we describe various uses of nonhuman primates for preclinical studies on menstruation, endometriosis, and as a model system to evaluate reproductive therapies and contraceptives. Our goal is to outline the strengths of the nonhuman primate model for studies leading to improved therapies for women.

    Original languageEnglish (US)
    Title of host publicationHandbook of Experimental Pharmacology
    PublisherSpringer New York LLC
    Pages191-202
    Number of pages12
    Volume232
    DOIs
    StatePublished - Apr 1 2016

    Publication series

    NameHandbook of Experimental Pharmacology
    Volume232
    ISSN (Print)01712004
    ISSN (Electronic)18650325

    Keywords

    • Animal models
    • Endometriosis
    • Menstruation
    • Nonhuman primate
    • Progesterone receptor modulators

    ASJC Scopus subject areas

    • Pharmacology, Toxicology and Pharmaceutics(all)
    • Biochemistry

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