Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn

Derry Ridgway, Gerda I. Benda, Ellen Magenis, Leland Allen, Gerald M. Segal, Rita Braziel, Robert C. Neerhout

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Abstract

TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21.

Original languageEnglish (US)
Pages (from-to)1117-1119
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume144
Issue number10
DOIs
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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