Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn

Derry Ridgway, Gerda I. Benda, Ellen Magenis, Leland Allen, Gerald M. Segal, Rita Braziel, Robert C. Neerhout

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21.

Original languageEnglish (US)
Pages (from-to)1117-1119
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume144
Issue number10
DOIs
StatePublished - 1990

Fingerprint

Myeloproliferative Disorders
Spontaneous Remission
Newborn Infant
Down Syndrome
Leukemia
Myeloid Progenitor Cells
Chromosomes, Human, Pair 21
Mosaicism
Trisomy
Phytohemagglutinins
Blood Cells
Clone Cells
Bone Marrow

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn. / Ridgway, Derry; Benda, Gerda I.; Magenis, Ellen; Allen, Leland; Segal, Gerald M.; Braziel, Rita; Neerhout, Robert C.

In: American Journal of Diseases of Children, Vol. 144, No. 10, 1990, p. 1117-1119.

Research output: Contribution to journalArticle

Ridgway, Derry ; Benda, Gerda I. ; Magenis, Ellen ; Allen, Leland ; Segal, Gerald M. ; Braziel, Rita ; Neerhout, Robert C. / Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn. In: American Journal of Diseases of Children. 1990 ; Vol. 144, No. 10. pp. 1117-1119.
@article{7ccce2ce37a240a79c80f5854d01245d,
title = "Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn",
abstract = "TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21.",
author = "Derry Ridgway and Benda, {Gerda I.} and Ellen Magenis and Leland Allen and Segal, {Gerald M.} and Rita Braziel and Neerhout, {Robert C.}",
year = "1990",
doi = "10.1001/archpedi.1990.02150340063024",
language = "English (US)",
volume = "144",
pages = "1117--1119",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "10",

}

TY - JOUR

T1 - Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn

AU - Ridgway, Derry

AU - Benda, Gerda I.

AU - Magenis, Ellen

AU - Allen, Leland

AU - Segal, Gerald M.

AU - Braziel, Rita

AU - Neerhout, Robert C.

PY - 1990

Y1 - 1990

N2 - TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21.

AB - TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21.

UR - http://www.scopus.com/inward/record.url?scp=0025127763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025127763&partnerID=8YFLogxK

U2 - 10.1001/archpedi.1990.02150340063024

DO - 10.1001/archpedi.1990.02150340063024

M3 - Article

C2 - 2144944

AN - SCOPUS:0025127763

VL - 144

SP - 1117

EP - 1119

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 10

ER -