Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes

L. J.N. Cooper, M. Kalos, D. A. Lewinsohn, S. R. Riddell, P. D. Greenberg

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

The introduction of genes encoding T-cell receptor (TCR) chains specific for human immunodeficiency virus into T cells of infected patients represents a means to quantitatively and qualitatively improve immunity to the virus. Our results demonstrate that the high level of TCR expression required for physiologic functioning can be reproducibly achieved with retroviral vectors encoding full-length unmodified TCR chains under the control of a strong internal constitutive phosphoglycerate kinase promoter.

Original languageEnglish (US)
Pages (from-to)8207-8212
Number of pages6
JournalJournal of virology
Volume74
Issue number17
DOIs
StatePublished - Sep 2 2000

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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