TY - JOUR
T1 - Transcriptional and post-transcriptional control of CNS myelination
AU - Emery, Ben
N1 - Funding Information:
I would like to thank B.A. Barres, S. Fancy and J. Xiao for helpful discussions and comments on this manuscript during preparation. This work was supported by a NHMRC CJ Martin award ( 400438 ) and an Australian Multiple Sclerosis Research Association grant.
PY - 2010/10
Y1 - 2010/10
N2 - The successful transduction of action potentials along vertebrate axons is highly reliant on myelin, the concentric layers of membrane surrounding most large diameter axons. Within the central nervous system myelin is produced by oligodendrocytes. Developmentally, the oligodendrocyte linage arises from subventricular zone progenitors that give rise to oligodendrocyte progenitor cells (OPCs), which divide and migrate throughout the CNS before terminally differentiating to generate mature oligodendrocytes which myelinate receptive axons. Each step of progression along the lineage is under tight transcriptional control, elucidation of this control is vital for understanding developmental myelination and for developing strategies to promote repair in demyelinating diseases. Recent studies have identified a number of new transcriptional regulators and microRNAs as having key roles in CNS myelination.
AB - The successful transduction of action potentials along vertebrate axons is highly reliant on myelin, the concentric layers of membrane surrounding most large diameter axons. Within the central nervous system myelin is produced by oligodendrocytes. Developmentally, the oligodendrocyte linage arises from subventricular zone progenitors that give rise to oligodendrocyte progenitor cells (OPCs), which divide and migrate throughout the CNS before terminally differentiating to generate mature oligodendrocytes which myelinate receptive axons. Each step of progression along the lineage is under tight transcriptional control, elucidation of this control is vital for understanding developmental myelination and for developing strategies to promote repair in demyelinating diseases. Recent studies have identified a number of new transcriptional regulators and microRNAs as having key roles in CNS myelination.
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U2 - 10.1016/j.conb.2010.05.005
DO - 10.1016/j.conb.2010.05.005
M3 - Review article
C2 - 20558055
AN - SCOPUS:77957016951
SN - 0959-4388
VL - 20
SP - 601
EP - 607
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -