Transcallosal sensorimotor fiber tract structure-function relationships

Brett Fling, Bryan L. Benson, Rachael D. Seidler

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Recent studies have demonstrated neuroanatomically selective relationships among white matter tract microstructure, physiological function, and task performance. Such findings suggest that the microstructure of transcallosal motor fibers may reflect the capacity for interhemispheric inhibition between the primary motor cortices, although full characterization of the transcallosal inhibitory sensorimotor network is lacking. Thus, the goal of this study was to provide a comprehensive description of transcallosal fibers connecting homologous sensorimotor cortical regions and to identify the relationship(s) between fiber tract microstructure and interhemispheric inhibition during voluntary cortical activity. To this end, we assessed microstructure of fiber tracts connecting homologous sensorimotor regions of the cortex with diffusion tensor imaging. We also assessed interhemispheric inhibition by eliciting the ipsilateral silent period (iSP) within the same participants. We mapped mutually exclusive transcallosal connections between homologous sensorimotor regions and computed quantitative metrics of each fiber tract. Paralleling work in non-human primates, we found the densest interhemispheric sensorimotor connections to be between the medial motor areas. Additionally, we provide a midsagittal callosal atlas in normalized Montreal Neurological Institute (MNI) space for future studies to use when investigating callosal fiber tracts connecting primary and secondary sensorimotor cortices. Finally, we report a strong, positive relationship (r = 0.76) between strength of interhemispheric inhibition (iSP) and microstructure of interhemispheric fibers that is specific to tracts connecting the primary motor cortices. Thus, increased fiber microstructure in young adults predicts interhemispheric inhibitory capacity. Hum Brain Mapp, 2013.

Original languageEnglish (US)
Pages (from-to)384-395
Number of pages12
JournalHuman Brain Mapping
Volume34
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Fingerprint

Motor Cortex
Corpus Callosum
Diffusion Tensor Imaging
Atlases
Task Performance and Analysis
Primates
Young Adult
Inhibition (Psychology)
Brain
Sensorimotor Cortex

Keywords

  • Corpus callosum
  • Diffusion tensor imaging
  • Interhemispheric inhibition
  • Ipsilateral silent period
  • Tractography

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Transcallosal sensorimotor fiber tract structure-function relationships. / Fling, Brett; Benson, Bryan L.; Seidler, Rachael D.

In: Human Brain Mapping, Vol. 34, No. 2, 02.2013, p. 384-395.

Research output: Contribution to journalArticle

Fling, Brett ; Benson, Bryan L. ; Seidler, Rachael D. / Transcallosal sensorimotor fiber tract structure-function relationships. In: Human Brain Mapping. 2013 ; Vol. 34, No. 2. pp. 384-395.
@article{c240970d60084d1cb0dc2a6c5a49ffb7,
title = "Transcallosal sensorimotor fiber tract structure-function relationships",
abstract = "Recent studies have demonstrated neuroanatomically selective relationships among white matter tract microstructure, physiological function, and task performance. Such findings suggest that the microstructure of transcallosal motor fibers may reflect the capacity for interhemispheric inhibition between the primary motor cortices, although full characterization of the transcallosal inhibitory sensorimotor network is lacking. Thus, the goal of this study was to provide a comprehensive description of transcallosal fibers connecting homologous sensorimotor cortical regions and to identify the relationship(s) between fiber tract microstructure and interhemispheric inhibition during voluntary cortical activity. To this end, we assessed microstructure of fiber tracts connecting homologous sensorimotor regions of the cortex with diffusion tensor imaging. We also assessed interhemispheric inhibition by eliciting the ipsilateral silent period (iSP) within the same participants. We mapped mutually exclusive transcallosal connections between homologous sensorimotor regions and computed quantitative metrics of each fiber tract. Paralleling work in non-human primates, we found the densest interhemispheric sensorimotor connections to be between the medial motor areas. Additionally, we provide a midsagittal callosal atlas in normalized Montreal Neurological Institute (MNI) space for future studies to use when investigating callosal fiber tracts connecting primary and secondary sensorimotor cortices. Finally, we report a strong, positive relationship (r = 0.76) between strength of interhemispheric inhibition (iSP) and microstructure of interhemispheric fibers that is specific to tracts connecting the primary motor cortices. Thus, increased fiber microstructure in young adults predicts interhemispheric inhibitory capacity. Hum Brain Mapp, 2013.",
keywords = "Corpus callosum, Diffusion tensor imaging, Interhemispheric inhibition, Ipsilateral silent period, Tractography",
author = "Brett Fling and Benson, {Bryan L.} and Seidler, {Rachael D.}",
year = "2013",
month = "2",
doi = "10.1002/hbm.21437",
language = "English (US)",
volume = "34",
pages = "384--395",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Transcallosal sensorimotor fiber tract structure-function relationships

AU - Fling, Brett

AU - Benson, Bryan L.

AU - Seidler, Rachael D.

PY - 2013/2

Y1 - 2013/2

N2 - Recent studies have demonstrated neuroanatomically selective relationships among white matter tract microstructure, physiological function, and task performance. Such findings suggest that the microstructure of transcallosal motor fibers may reflect the capacity for interhemispheric inhibition between the primary motor cortices, although full characterization of the transcallosal inhibitory sensorimotor network is lacking. Thus, the goal of this study was to provide a comprehensive description of transcallosal fibers connecting homologous sensorimotor cortical regions and to identify the relationship(s) between fiber tract microstructure and interhemispheric inhibition during voluntary cortical activity. To this end, we assessed microstructure of fiber tracts connecting homologous sensorimotor regions of the cortex with diffusion tensor imaging. We also assessed interhemispheric inhibition by eliciting the ipsilateral silent period (iSP) within the same participants. We mapped mutually exclusive transcallosal connections between homologous sensorimotor regions and computed quantitative metrics of each fiber tract. Paralleling work in non-human primates, we found the densest interhemispheric sensorimotor connections to be between the medial motor areas. Additionally, we provide a midsagittal callosal atlas in normalized Montreal Neurological Institute (MNI) space for future studies to use when investigating callosal fiber tracts connecting primary and secondary sensorimotor cortices. Finally, we report a strong, positive relationship (r = 0.76) between strength of interhemispheric inhibition (iSP) and microstructure of interhemispheric fibers that is specific to tracts connecting the primary motor cortices. Thus, increased fiber microstructure in young adults predicts interhemispheric inhibitory capacity. Hum Brain Mapp, 2013.

AB - Recent studies have demonstrated neuroanatomically selective relationships among white matter tract microstructure, physiological function, and task performance. Such findings suggest that the microstructure of transcallosal motor fibers may reflect the capacity for interhemispheric inhibition between the primary motor cortices, although full characterization of the transcallosal inhibitory sensorimotor network is lacking. Thus, the goal of this study was to provide a comprehensive description of transcallosal fibers connecting homologous sensorimotor cortical regions and to identify the relationship(s) between fiber tract microstructure and interhemispheric inhibition during voluntary cortical activity. To this end, we assessed microstructure of fiber tracts connecting homologous sensorimotor regions of the cortex with diffusion tensor imaging. We also assessed interhemispheric inhibition by eliciting the ipsilateral silent period (iSP) within the same participants. We mapped mutually exclusive transcallosal connections between homologous sensorimotor regions and computed quantitative metrics of each fiber tract. Paralleling work in non-human primates, we found the densest interhemispheric sensorimotor connections to be between the medial motor areas. Additionally, we provide a midsagittal callosal atlas in normalized Montreal Neurological Institute (MNI) space for future studies to use when investigating callosal fiber tracts connecting primary and secondary sensorimotor cortices. Finally, we report a strong, positive relationship (r = 0.76) between strength of interhemispheric inhibition (iSP) and microstructure of interhemispheric fibers that is specific to tracts connecting the primary motor cortices. Thus, increased fiber microstructure in young adults predicts interhemispheric inhibitory capacity. Hum Brain Mapp, 2013.

KW - Corpus callosum

KW - Diffusion tensor imaging

KW - Interhemispheric inhibition

KW - Ipsilateral silent period

KW - Tractography

UR - http://www.scopus.com/inward/record.url?scp=84871988990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871988990&partnerID=8YFLogxK

U2 - 10.1002/hbm.21437

DO - 10.1002/hbm.21437

M3 - Article

C2 - 22042512

AN - SCOPUS:84871988990

VL - 34

SP - 384

EP - 395

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 2

ER -