Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities

Anthony E. Pusateri; Richard B. Weiskopf; Vikhyat Bebarta; Frank Butler; Ramon F. Cestero; Irshad H. Chaudry; Virgil Deal; Warren C. Dorlac; Robert T. Gerhardt; Michael B. Given; Dan R. Hansen; W. Keith Hoots; Harvey G. Klein; Victor W. MacDonald; Kenneth L. Mattox; Rodney A. Michael; Jon Mogford; Elizabeth A. Montcalm-Smith; Debra M. Niemeyer; W. Keith Prusaczyk; Joseph F. Rappold; Todd Rassmussen; Francisco Rentas; James Ross; Christopher Thompson; Leo D. Tucker

doi:10.1097/SHK.0b013e318280409a

Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities

Anthony E. Pusateri, Richard B. Weiskopf, Vikhyat Bebarta, Frank Butler, Ramon F. Cestero, Irshad H. Chaudry, Virgil Deal, Warren C. Dorlac, Robert T. Gerhardt, Michael B. Given, Dan R. Hansen, W. Keith Hoots, Harvey G. Klein, Victor W. MacDonald, Kenneth L. Mattox, Rodney A. Michael, Jon Mogford, Elizabeth A. Montcalm-Smith, Debra M. Niemeyer, W. Keith PrusaczykJoseph F. Rappold, Todd Rassmussen, Francisco Rentas, James Ross, Christopher Thompson, Leo D. Tucker

Research output: Contribution to journal › Review article › peer-review

88 Scopus citations

Abstract

A recent large civilian randomized controlled trial on the use of tranexamic acid (TXA) for trauma reported important survival benefits. Subsequently, successful use of TXA for combat casualties in Afghanistan was also reported. As a result of these promising studies, there has been growing interest in the use of TXA for trauma. Potential adverse effects of TXA have also been reported. A US Department of Defense committee conducted a review and assessment of knowledge gaps and research requirements regarding the use of TXA for the treatment of casualties that have experienced traumatic hemorrhage. We present identified knowledge gaps and associated research priorities. We believe that important knowledge gaps exist and that a targeted, prioritized research effort will contribute to the refinement of practice guidelines over time.

Original language	English (US)
Pages (from-to)	121-126
Number of pages	6
Journal	Shock
Volume	39
Issue number	2
DOIs	https://doi.org/10.1097/SHK.0b013e318280409a
State	Published - Feb 2013
Externally published	Yes

Keywords

Tranexamic acid
efficacy
research requirements
safety
trauma

ASJC Scopus subject areas

Emergency Medicine
Critical Care and Intensive Care Medicine

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10.1097/SHK.0b013e318280409a

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Pusateri, A. E., Weiskopf, R. B., Bebarta, V., Butler, F., Cestero, R. F., Chaudry, I. H., Deal, V., Dorlac, W. C., Gerhardt, R. T., Given, M. B., Hansen, D. R., Hoots, W. K., Klein, H. G., MacDonald, V. W., Mattox, K. L., Michael, R. A., Mogford, J., Montcalm-Smith, E. A., Niemeyer, D. M., ... Tucker, L. D. (2013). Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities. Shock, 39(2), 121-126. https://doi.org/10.1097/SHK.0b013e318280409a

Pusateri, AE, Weiskopf, RB, Bebarta, V, Butler, F, Cestero, RF, Chaudry, IH, Deal, V, Dorlac, WC, Gerhardt, RT, Given, MB, Hansen, DR, Hoots, WK, Klein, HG, MacDonald, VW, Mattox, KL, Michael, RA, Mogford, J, Montcalm-Smith, EA, Niemeyer, DM, Prusaczyk, WK, Rappold, JF, Rassmussen, T, Rentas, F, Ross, J, Thompson, C & Tucker, LD 2013, 'Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities', Shock, vol. 39, no. 2, pp. 121-126. https://doi.org/10.1097/SHK.0b013e318280409a

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AU - Michael, Rodney A.

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AU - Montcalm-Smith, Elizabeth A.

AU - Niemeyer, Debra M.

AU - Prusaczyk, W. Keith

AU - Rappold, Joseph F.

AU - Rassmussen, Todd

AU - Rentas, Francisco

AU - Ross, James

AU - Thompson, Christopher

AU - Tucker, Leo D.

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Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities

Abstract

Keywords

ASJC Scopus subject areas

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