Trajectory of mild cognitive impairment onset

Diane Howieson, Nichole E. Carlson, M. Milar Moore, Dara Wasserman, Cena D. Abendroth, Jessica Payne-Murphy, Jeffrey Kaye

Research output: Contribution to journalArticle

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Abstract

The objective was to identify the trajectories of onset of memory and other cognitive loss in persons destined to develop mild cognitive impairment (MCI) or dementia. Healthy, community dwelling, cognitively intact elders (n = 156, mean age at entry = 83 years) were examined annually for an average of greater than 7 years. Those who developed at least two consecutive Clinical Dementia Ratings ≥ 0.5 were classified as having MCI. Longitudinal mixed effects models with a change point were used to model the aging process in those with and without an MCI diagnosis during follow-up and to model the rate of change relative to the age of onset of MCI. MCI had a preclinical stage of accelerated cognitive loss that was observed 3 to 4 years before the diagnosis of MCI on tests of verbal memory, animal fluency, and visuospatial constructions. Evidence from memory performance before the change point suggests that a slow decline in memory precedes the period of accelerated decline in the development of MCI. Aging transitions leading to MCI and dementia are characterized by unique linear and nonlinear cognitive changes in several domains that precede the diagnosis of MCI and dementia by at least several years.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
JournalJournal of the International Neuropsychological Society
Volume14
Issue number2
DOIs
StatePublished - Mar 2008

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Dementia
Independent Living
Cognitive Dysfunction
Age of Onset

Keywords

  • Aged 80 and over
  • Aging
  • Alzheimer disease
  • Dementia
  • Episodic memory
  • Longitudinal studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Howieson, D., Carlson, N. E., Moore, M. M., Wasserman, D., Abendroth, C. D., Payne-Murphy, J., & Kaye, J. (2008). Trajectory of mild cognitive impairment onset. Journal of the International Neuropsychological Society, 14(2), 192-198. https://doi.org/10.1017/S1355617708080375

Trajectory of mild cognitive impairment onset. / Howieson, Diane; Carlson, Nichole E.; Moore, M. Milar; Wasserman, Dara; Abendroth, Cena D.; Payne-Murphy, Jessica; Kaye, Jeffrey.

In: Journal of the International Neuropsychological Society, Vol. 14, No. 2, 03.2008, p. 192-198.

Research output: Contribution to journalArticle

Howieson, D, Carlson, NE, Moore, MM, Wasserman, D, Abendroth, CD, Payne-Murphy, J & Kaye, J 2008, 'Trajectory of mild cognitive impairment onset', Journal of the International Neuropsychological Society, vol. 14, no. 2, pp. 192-198. https://doi.org/10.1017/S1355617708080375
Howieson D, Carlson NE, Moore MM, Wasserman D, Abendroth CD, Payne-Murphy J et al. Trajectory of mild cognitive impairment onset. Journal of the International Neuropsychological Society. 2008 Mar;14(2):192-198. https://doi.org/10.1017/S1355617708080375
Howieson, Diane ; Carlson, Nichole E. ; Moore, M. Milar ; Wasserman, Dara ; Abendroth, Cena D. ; Payne-Murphy, Jessica ; Kaye, Jeffrey. / Trajectory of mild cognitive impairment onset. In: Journal of the International Neuropsychological Society. 2008 ; Vol. 14, No. 2. pp. 192-198.
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