Traffic Jams during Vesicle Cycling Lead to Synaptic Depression

Jun Hee Kim; Henrique von Gersdorff

doi:10.1016/j.neuron.2009.07.006

Traffic Jams during Vesicle Cycling Lead to Synaptic Depression

Jun Hee Kim, Henrique von Gersdorff

Vollum Institute

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that [Ca²⁺]_i-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.

Original language	English (US)
Pages (from-to)	143-145
Number of pages	3
Journal	Neuron
Volume	63
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2009.07.006
State	Published - Jul 30 2009

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2009.07.006

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title = "Traffic Jams during Vesicle Cycling Lead to Synaptic Depression",

abstract = "During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that [Ca2+]i-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.",

author = "Kim, {Jun Hee} and {von Gersdorff}, Henrique",

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AU - Kim, Jun Hee

AU - von Gersdorff, Henrique

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AB - During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that [Ca2+]i-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.

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Traffic Jams during Vesicle Cycling Lead to Synaptic Depression

Abstract

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