Traffic Jams during Vesicle Cycling Lead to Synaptic Depression

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations


During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that [Ca2+]i-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
Issue number2
StatePublished - Jul 30 2009

ASJC Scopus subject areas

  • Neuroscience(all)


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