Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Mathieu Gissot, Sang Woon Choi, Reid F. Thompson, John M. Greally, Kami Kim

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

Original languageEnglish (US)
Pages (from-to)537-540
Number of pages4
JournalEukaryotic Cell
Volume7
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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