Toxic megacolon

A life-threatening complication of high-dose therapy and autologous stem cell transplantation among patients with AL amyloidosis

Brandon Hayes-Lattin, P. T. Curtin, William Fleming, J. F. Leis, D. E. Stepan, S. Schubach, Richard Maziarz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

AL amyloidosis is a plasma cell disorder in which tissue deposition of immunoglobulin light chains leads to organ dysfunction. Recent reports of high-dose therapy with autologous stem cell transplantation for amyloidosis suggest higher response rates and extended survival compared to those seen with conventional chemotherapy. However, substantial treatment-related toxicity has been observed. This case series describes our institutional experience with autologous transplantation in four patients with amyloidosis with an emphasis on unique gastrointestinal toxicities, including toxic megacolon.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalBone Marrow Transplantation
Volume30
Issue number5
DOIs
StatePublished - Sep 2002

Fingerprint

Toxic Megacolon
Stem Cell Transplantation
Amyloidosis
Immunoglobulin Light Chains
Autologous Transplantation
Plasma Cells
Therapeutics
Survival Rate
Drug Therapy

Keywords

  • AL amyloidosis
  • High-dose chemotherapy
  • Stem cell transplantation
  • Toxic megacolon

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Toxic megacolon : A life-threatening complication of high-dose therapy and autologous stem cell transplantation among patients with AL amyloidosis. / Hayes-Lattin, Brandon; Curtin, P. T.; Fleming, William; Leis, J. F.; Stepan, D. E.; Schubach, S.; Maziarz, Richard.

In: Bone Marrow Transplantation, Vol. 30, No. 5, 09.2002, p. 279-285.

Research output: Contribution to journalArticle

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