Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale

Thomas F. Budinger, Mark D. Bird, Lucio Frydman, Joanna R. Long, Thomas H. Mareci, William D. Rooney, Bruce Rosen, John F. Schenck, Victor D. Schepkin, A. Dean Sherry, Daniel K. Sodickson, Charles S. Springer, Keith R. Thulborn, Kamil Uğurbil, Lawrence L. Wald

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.

Original languageEnglish (US)
Pages (from-to)617-639
Number of pages23
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume29
Issue number3
DOIs
StatePublished - Jun 1 2016

Keywords

  • Diffusion tensor imaging
  • High temperature superconductors
  • Human brain chemistry
  • Magnetic field physiologic effects
  • Magnetic resonance imaging
  • Parallel transmit and receive strategies
  • Ultrahigh magnetic fields

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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