Abstract
Objectives: Tissue confirmation of the intrauterine location of a pregnancy can be difficult grossly, necessitating a frozen section diagnosis. First-trimester tissue is often scant and can be exhausted by frozen section. We examined 39 endometrial curettings performed for rule-out ectopic pregnancy by touch prep to examine the utility of cytopathology in documenting trophoblast or chorionic villi (products of conception [POC]). Methods: First-trimester curettage specimens sent to the Massachusetts General Hospital Pathology Departmentreceived a gross examination followed by a touch prep of the area most suspicious for villi. Touch preps were reviewed blinded to the final diagnosis and then compared. Results: Thirty-three of the 39 touch preps and histology specimens were concordant, including all 11 negative histology specimens and 22 of the 28 positive histology specimens. Conclusions: POC can be diagnosed by touch prep and may offer confirmation of grossly identified villi. Positive predictive value is 100%. Negative touch preps should receive further evaluation.
Original language | English (US) |
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Pages (from-to) | 752-756 |
Number of pages | 5 |
Journal | American journal of clinical pathology |
Volume | 145 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2016 |
Externally published | Yes |
Keywords
- Cytopathology
- Ectopic pregnancy
- Touch prep
ASJC Scopus subject areas
- Pathology and Forensic Medicine