Touch preps of products of conception for rule-out ectopic pregnancy a viable alternative to frozen section

Athena L. Chen, Rosemary H. Tambouret, Drucilla J. Roberts

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objectives: Tissue confirmation of the intrauterine location of a pregnancy can be difficult grossly, necessitating a frozen section diagnosis. First-trimester tissue is often scant and can be exhausted by frozen section. We examined 39 endometrial curettings performed for rule-out ectopic pregnancy by touch prep to examine the utility of cytopathology in documenting trophoblast or chorionic villi (products of conception [POC]). Methods: First-trimester curettage specimens sent to the Massachusetts General Hospital Pathology Departmentreceived a gross examination followed by a touch prep of the area most suspicious for villi. Touch preps were reviewed blinded to the final diagnosis and then compared. Results: Thirty-three of the 39 touch preps and histology specimens were concordant, including all 11 negative histology specimens and 22 of the 28 positive histology specimens. Conclusions: POC can be diagnosed by touch prep and may offer confirmation of grossly identified villi. Positive predictive value is 100%. Negative touch preps should receive further evaluation.

Original languageEnglish (US)
Pages (from-to)752-756
Number of pages5
JournalAmerican journal of clinical pathology
Volume145
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • Cytopathology
  • Ectopic pregnancy
  • Touch prep

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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