Topology of signal recognition particle receptor in endoplasmic reticulum membrane

Leander Lauffer, Pablo D. Garcia, Richard N. Harkins, Lisa Coussens, Axel Ullrich, Peter Walter

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

The signal recognition particle (SRP) receptor is an integral membrane protein of the endoplasmic reticulum which, in conjunction with SRP, ensures the correct targeting of nascent secretory proteins to this membrane system. From the complementary DNA sequence we have deduced the complete primary structure of the SRP receptor and established that its amino-terminal region is anchored in the membrane. The anchor fragment and the cytoplasmic fragment contribute jointly to a functionally important region which is highly charged and may function in nucleic acid binding.

Original languageEnglish (US)
Pages (from-to)334-338
Number of pages5
JournalNature
Volume318
Issue number6044
DOIs
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • General

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    Lauffer, L., Garcia, P. D., Harkins, R. N., Coussens, L., Ullrich, A., & Walter, P. (1985). Topology of signal recognition particle receptor in endoplasmic reticulum membrane. Nature, 318(6044), 334-338. https://doi.org/10.1038/318334a0