Topical treatment of alopecia areata. Contact allergen vs primary irritant therapy

Neil Swanson, A. J. Mitchell, M. S. Leahy, J. T. Headington, L. A. Diaz

Research output: Contribution to journalArticle

Abstract

It has been shown previously that alopecia areata can be treated with dinitrochlorobenzene (DNCB) and other contact allergens. Whether these agents work by inducing immunologic stimulation or simply a nonspecific inflammatory reaction has not been definitively demonstrated. To test the relative importance of these two mechanisms, we have randomly studied 22 patients with alopecia areata to whom either DNCB or croton oil was applied topically. Sixty-three percentage of patients without spontaneous regrowth of hair regrew hair after DNCB application. None of those treated with croton oil responded. Patients initially treated with croton oil regrew hair when treated later with DNCB. Therefore, a proved contact allergen was shown to be required for therapeutic success. Patient acceptance of the induced contact dermatitis was excellent. In light of recent data on the mutagenicity of DNCB to bacteria, other contact allergens for topical immunotherapy are being sought.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalArchives of Dermatology
Volume117
Issue number7
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Alopecia Areata
Dinitrochlorobenzene
Irritants
Allergens
Croton Oil
Hair
Immunologic Desensitization
Therapeutics
Contact Dermatitis
Immunization
Bacteria

ASJC Scopus subject areas

  • Dermatology

Cite this

Swanson, N., Mitchell, A. J., Leahy, M. S., Headington, J. T., & Diaz, L. A. (1981). Topical treatment of alopecia areata. Contact allergen vs primary irritant therapy. Archives of Dermatology, 117(7), 384-387. https://doi.org/10.1001/archderm.117.7.384

Topical treatment of alopecia areata. Contact allergen vs primary irritant therapy. / Swanson, Neil; Mitchell, A. J.; Leahy, M. S.; Headington, J. T.; Diaz, L. A.

In: Archives of Dermatology, Vol. 117, No. 7, 1981, p. 384-387.

Research output: Contribution to journalArticle

Swanson, N, Mitchell, AJ, Leahy, MS, Headington, JT & Diaz, LA 1981, 'Topical treatment of alopecia areata. Contact allergen vs primary irritant therapy', Archives of Dermatology, vol. 117, no. 7, pp. 384-387. https://doi.org/10.1001/archderm.117.7.384
Swanson, Neil ; Mitchell, A. J. ; Leahy, M. S. ; Headington, J. T. ; Diaz, L. A. / Topical treatment of alopecia areata. Contact allergen vs primary irritant therapy. In: Archives of Dermatology. 1981 ; Vol. 117, No. 7. pp. 384-387.
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