Abstract
PURPOSE OF REVIEW: Ocular surface squamous neoplasia (OSSN) is an umbrella term for a spectrum of epithelial dysplasias of the cornea, conjunctiva, and limbus. Treatment for OSSN has historically been surgery, but nonsurgical interventions have been increasingly adopted. Advantages of medical treatments include the ability to treat the entire ocular surface and prevention of surgical complications. RECENT FINDINGS: The primary medical treatments for OSSN include mitomycin C, 5-fluorouracil, and interferon α2b. Mitomycin C has been shown in studies to be highly effective but has short-term and long-term side-effects that may be intolerable. 5-Fluorouracil and interferon α2b have been found to be similar in efficacy to mitomycin, with interferon being extremely well tolerated in the majority of patients. Most recently, other chemotherapeutic agents have been tried for OSSN including antivascular endothelial growth factor agents and vitamin A. The data regarding these latter treatment strategies are still limited. SUMMARY: An understanding of the recent literature, with respect to the efficacy, advantages, and disadvantages of the various therapies for OSSN will allow us to tailor treatment to each patient.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 336-342 |
| Number of pages | 7 |
| Journal | Current Opinion in Ophthalmology |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2013 |
| Externally published | Yes |
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Keywords
- 5-fluorouracil
- interferon
- mitomycin C
- ocular surface squamous neoplasia
- topical chemotherapy
ASJC Scopus subject areas
- Ophthalmology
Cite this
Topical chemotherapy for ocular surface squamous neoplasia. / Nanji, Afshan; Sayyad, Fouad E.; Karp, Carol L.
In: Current Opinion in Ophthalmology, Vol. 24, No. 4, 07.2013, p. 336-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topical chemotherapy for ocular surface squamous neoplasia
AU - Nanji, Afshan
AU - Sayyad, Fouad E.
AU - Karp, Carol L.
PY - 2013/7
Y1 - 2013/7
N2 - PURPOSE OF REVIEW: Ocular surface squamous neoplasia (OSSN) is an umbrella term for a spectrum of epithelial dysplasias of the cornea, conjunctiva, and limbus. Treatment for OSSN has historically been surgery, but nonsurgical interventions have been increasingly adopted. Advantages of medical treatments include the ability to treat the entire ocular surface and prevention of surgical complications. RECENT FINDINGS: The primary medical treatments for OSSN include mitomycin C, 5-fluorouracil, and interferon α2b. Mitomycin C has been shown in studies to be highly effective but has short-term and long-term side-effects that may be intolerable. 5-Fluorouracil and interferon α2b have been found to be similar in efficacy to mitomycin, with interferon being extremely well tolerated in the majority of patients. Most recently, other chemotherapeutic agents have been tried for OSSN including antivascular endothelial growth factor agents and vitamin A. The data regarding these latter treatment strategies are still limited. SUMMARY: An understanding of the recent literature, with respect to the efficacy, advantages, and disadvantages of the various therapies for OSSN will allow us to tailor treatment to each patient.
AB - PURPOSE OF REVIEW: Ocular surface squamous neoplasia (OSSN) is an umbrella term for a spectrum of epithelial dysplasias of the cornea, conjunctiva, and limbus. Treatment for OSSN has historically been surgery, but nonsurgical interventions have been increasingly adopted. Advantages of medical treatments include the ability to treat the entire ocular surface and prevention of surgical complications. RECENT FINDINGS: The primary medical treatments for OSSN include mitomycin C, 5-fluorouracil, and interferon α2b. Mitomycin C has been shown in studies to be highly effective but has short-term and long-term side-effects that may be intolerable. 5-Fluorouracil and interferon α2b have been found to be similar in efficacy to mitomycin, with interferon being extremely well tolerated in the majority of patients. Most recently, other chemotherapeutic agents have been tried for OSSN including antivascular endothelial growth factor agents and vitamin A. The data regarding these latter treatment strategies are still limited. SUMMARY: An understanding of the recent literature, with respect to the efficacy, advantages, and disadvantages of the various therapies for OSSN will allow us to tailor treatment to each patient.
KW - 5-fluorouracil
KW - interferon
KW - mitomycin C
KW - ocular surface squamous neoplasia
KW - topical chemotherapy
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UR - http://www.scopus.com/inward/citedby.url?scp=84880133204&partnerID=8YFLogxK
U2 - 10.1097/ICU.0b013e3283622a13
DO - 10.1097/ICU.0b013e3283622a13
M3 - Article
VL - 24
SP - 336
EP - 342
JO - Current Opinion in Ophthalmology
JF - Current Opinion in Ophthalmology
SN - 1040-8738
IS - 4
ER -