Tonic inhibition of striatal dopamine transmission: effects of benzodiazepine and GABAA receptor antagonists on extracellular dopamine levels

Rand J. Gruen, Arnold J. Friedhoff, Anne Coale, Bita Moghaddam

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

At present, it is unclear whether ligands which bind at the benzodiazepine/GABA receptor complex play a tonic modulatory role with regard to striatal dopamine (DA) transmission. The present study was designed to examine the effects of Ro15-1788, a benzodiazepine (BZ) receptor antagonist, and SR 95531, a GABAA receptor antagonist, on striatal extracellular DA (DA[e]) concentrations in anesthetized and awake rats using the technique of in vivo microdialysis. Local administration of Ro15-1788 resulted in a dose-dependent increase in DA[e] in both anesthetized and awake animals. The Ro15-1788-induced increase in DA[e] was blocked by coadministration of the BZ agonist diazepam, as well as GABA. Local administration of SR 95531 also resulted in a dose-dependent alteration in striatal DA levels in both anesthetized and awake animals. The SR 95531-induced increase in DA was blocked by coadministration of GABA. The results suggest that GABA may play a tonic inhibitory role with regard to striatal DA transmission.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalBrain Research
Volume599
Issue number1
DOIs
StatePublished - Dec 18 1992
Externally publishedYes

Fingerprint

GABA-A Receptor Antagonists
Corpus Striatum
Dopamine Agents
GABA-A Receptors
Dopamine
gamma-Aminobutyric Acid
Microdialysis
Diazepam
Benzodiazepines
Ligands

Keywords

  • Benzodiazepine
  • Dopamine
  • Microdialysis
  • Ro15-1788
  • SR 95531
  • Striatum
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tonic inhibition of striatal dopamine transmission : effects of benzodiazepine and GABAA receptor antagonists on extracellular dopamine levels. / Gruen, Rand J.; Friedhoff, Arnold J.; Coale, Anne; Moghaddam, Bita.

In: Brain Research, Vol. 599, No. 1, 18.12.1992, p. 51-56.

Research output: Contribution to journalArticle

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