Tonic excitation and inhibition of neurons: Ambient transmitter sources and computational consequences

Pauline Cavelier, Martine Hamann, David Rossi, Peter Mobbs, David Attwell

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Tonic activation of excitatory and inhibitory receptors, by the ambient concentration of neurotransmitters in the extracellular space of the brain, has been suggested to underlie phenomena as diverse as relapse to cocaine use by reward pathways in the striatum, sparse coding of motor information in the cerebellum, and control of the development of the cerebral and cerebellar cortices. Here we assess the mechanisms which may determine the ambient levels of excitatory and inhibitory neurotransmitters, and consider their likely effect on information processing.

Original languageEnglish (US)
Pages (from-to)3-16
Number of pages14
JournalProgress in Biophysics and Molecular Biology
Volume87
Issue number1 SPEC. ISS.
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Neurotransmitter Agents
Neurons
Cerebellar Cortex
Extracellular Space
Reward
Automatic Data Processing
Cocaine
Cerebral Cortex
Cerebellum
Recurrence
Brain
Inhibition (Psychology)

Keywords

  • Ambient
  • Extracellular
  • GABA
  • Glutamate
  • Release
  • Tonic
  • Uptake

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics

Cite this

Tonic excitation and inhibition of neurons : Ambient transmitter sources and computational consequences. / Cavelier, Pauline; Hamann, Martine; Rossi, David; Mobbs, Peter; Attwell, David.

In: Progress in Biophysics and Molecular Biology, Vol. 87, No. 1 SPEC. ISS., 01.2005, p. 3-16.

Research output: Contribution to journalArticle

Cavelier, Pauline ; Hamann, Martine ; Rossi, David ; Mobbs, Peter ; Attwell, David. / Tonic excitation and inhibition of neurons : Ambient transmitter sources and computational consequences. In: Progress in Biophysics and Molecular Biology. 2005 ; Vol. 87, No. 1 SPEC. ISS. pp. 3-16.
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