Tolerance to ethanol hypothermia in HOT and COLD mice

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

COLD and HOT mice have been selected to be sensitive or resistant, respectively, to the acute hypothermic effect of ethanol. Previous studies have found HOT mice to be relatively resistant to the development of tolerance to this effect, whereas COLD mice readily develop tolerance. By administering several doses of ethanol and recording multiple postdrug temperatures, in the current study we equated the selected lines for area under the curve describing initial hypothermic response over time, a measure reflecting both maximal hypothermia achieved and the duration of total hypothermia response. The dose-response function for COLD mice was much steeper than that for HOT mice, and HOT mice recovered to baseline body temperatures more slowly. Doses were administered daily for 5 days. Both lines developed tolerance to ethanol hypothermia. The magnitude of tolerance developed was greater in COLD than in HOT mice. At higher doses, HOT mice showed a progressively enhanced hypothermic response over days (i.e., sensitization).

Original languageEnglish (US)
Pages (from-to)42-46
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume18
Issue number1
StatePublished - 1994

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Hypothermia
Ethanol
Temperature
Body Temperature
Area Under Curve

Keywords

  • Ethanol
  • HOT/COLD Selected Lines
  • Hypothermia
  • Pharmacogenetics
  • Sensitization
  • Tolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Tolerance to ethanol hypothermia in HOT and COLD mice. / Crabbe, John Jr.

In: Alcoholism: Clinical and Experimental Research, Vol. 18, No. 1, 1994, p. 42-46.

Research output: Contribution to journalArticle

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