Tolerance and withdrawal in goldfish exposed to ethanol

Larry I. Crawshaw, Helen L. Wallace, Candace S. O'Connor, Tamae Yoda, John Jr Crabbe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acute ethanol exposure decreases regulated body temperature. Tolerance and dependence develop with continued exposure. Removal of ethanol following chronic exposure produces withdrawal. There is little information on the time course for the development of tolerance and disagreement about the presence of a rebound effect on body temperature during withdrawal. For tolerance, we monitored the selected temperature [Tsel] of goldfish [Carassius auratus] for 8 h while they were exposed to one of three doses of ethanol. During the period from 90 to 150 min post-exposure, Tsel was: control: 24.1 ± 0.07°C; 0.4% ethanol: 21.9 ± 0.09°C; 0.8% ethanol: 21.3 ± 0.05°C; 1.1% ethanol: 18.4 ± 0.10°C. The difference between control and experimental Tsel decreased by the following amounts for the final 1.5 h in the gradient: 0.4% ethanol: 2.60 ± 0.12°C; 0.8% ethanol: 1.58 ± 0.09°C; 1.1% ethanol: 4.08 ± 0.12°C. At all 3 doses, tolerance proceeded in a stepwise manner rather than continuously. Temperature regulation during withdrawal was evaluated by maintaining the goldfish in 0.8% ethanol for three days and subsequently monitoring Tsel in an ethanol-free temperature gradient for 36 h. During withdrawal there was no evidence for an effect on Tsel; experimental and control values were nearly identical.

Original languageEnglish (US)
Pages (from-to)460-468
Number of pages9
JournalPhysiology and Behavior
Volume87
Issue number3
DOIs
StatePublished - Mar 30 2006

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Goldfish
Ethanol
Body Temperature
Temperature

Keywords

  • Activity
  • Alcohol
  • Temperature regulation
  • Temperature selection

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

Tolerance and withdrawal in goldfish exposed to ethanol. / Crawshaw, Larry I.; Wallace, Helen L.; O'Connor, Candace S.; Yoda, Tamae; Crabbe, John Jr.

In: Physiology and Behavior, Vol. 87, No. 3, 30.03.2006, p. 460-468.

Research output: Contribution to journalArticle

Crawshaw, Larry I. ; Wallace, Helen L. ; O'Connor, Candace S. ; Yoda, Tamae ; Crabbe, John Jr. / Tolerance and withdrawal in goldfish exposed to ethanol. In: Physiology and Behavior. 2006 ; Vol. 87, No. 3. pp. 460-468.
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