TNF-α in rheumatoid arthritis and prospects of anti-TNF therapy

R. N. Maini, F. M. Brennan, R. Williams, Cong-Qiu Chu, A. P. Cope, D. Gibbons, M. Elliott, M. Feldmann

Research output: Contribution to journalArticle

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Abstract

Our work has shown that TNFα is produced by cultured mononuclear cells from rheumatoid arthritis joints and appears to regulate the production of IL-1. Immunohistochemical examination has shown the presence of TNFα in the synovium, e.g. in the lining layer, some endothelial cells and most importantly, in the cells in the cartilage pannus junction. TNF receptors (both p55 and p75) have a similar distribution, thereby suggesting that TNF has the potential for autocrine and paracrine activity in the joint. The concept that TNFα is pathogenic in inflammatory arthritis has been validated by showing that neutralizing monoclonal anti-TNF antibodies significantly attenuate collagen-induced arthritis in mice. In preliminary trials in rheumatoid patients anti-TNF appears to have an impressive effect on indices of disease activity including C-reactive production and serum amyloid-A production. TNFα appears to be a relevant therapeutic target in rheumatoid disease.

Original languageEnglish (US)
JournalClinical and Experimental Rheumatology
Volume11
Issue numberSUPPL. 8
StatePublished - 1993
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
Joints
Serum Amyloid A Protein
Experimental Arthritis
Synovial Membrane
Interleukin-1
Arthritis
Cartilage
Anti-Idiotypic Antibodies
Cultured Cells
Endothelial Cells
Monoclonal Antibodies
Therapeutics
recombinant human tumor necrosis factor-binding protein-1

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Maini, R. N., Brennan, F. M., Williams, R., Chu, C-Q., Cope, A. P., Gibbons, D., ... Feldmann, M. (1993). TNF-α in rheumatoid arthritis and prospects of anti-TNF therapy. Clinical and Experimental Rheumatology, 11(SUPPL. 8).

TNF-α in rheumatoid arthritis and prospects of anti-TNF therapy. / Maini, R. N.; Brennan, F. M.; Williams, R.; Chu, Cong-Qiu; Cope, A. P.; Gibbons, D.; Elliott, M.; Feldmann, M.

In: Clinical and Experimental Rheumatology, Vol. 11, No. SUPPL. 8, 1993.

Research output: Contribution to journalArticle

Maini, RN, Brennan, FM, Williams, R, Chu, C-Q, Cope, AP, Gibbons, D, Elliott, M & Feldmann, M 1993, 'TNF-α in rheumatoid arthritis and prospects of anti-TNF therapy', Clinical and Experimental Rheumatology, vol. 11, no. SUPPL. 8.
Maini RN, Brennan FM, Williams R, Chu C-Q, Cope AP, Gibbons D et al. TNF-α in rheumatoid arthritis and prospects of anti-TNF therapy. Clinical and Experimental Rheumatology. 1993;11(SUPPL. 8).
Maini, R. N. ; Brennan, F. M. ; Williams, R. ; Chu, Cong-Qiu ; Cope, A. P. ; Gibbons, D. ; Elliott, M. ; Feldmann, M. / TNF-α in rheumatoid arthritis and prospects of anti-TNF therapy. In: Clinical and Experimental Rheumatology. 1993 ; Vol. 11, No. SUPPL. 8.
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