Tissue localization during resective epilepsy surgery

Sandra L. Poliachik, Andrew V. Poliakov, Laura A. Jansen, Sharon S. McDaniel, Carter Wray, John Kuratani, Russell P. Saneto, Jeffrey G. Ojemann, Edward J. Novotny

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Object. Imaging-guided surgery (IGS) systems are widely used in neurosurgical practice. During epilepsy surgery, the authors routinely use IGS landmarks to localize intracranial electrodes and/or specific brain regions. The authors have developed a technique to coregister these landmarks with pre- and postoperative scans and the Montreal Neurological Institute (MNI) standard space brain MRI to allow 1) localization and identification of tissue anatomy; and 2) identification of Brodmann areas (BAs) of the tissue resected during epilepsy surgery. Tracking tissue in this fashion allows for better correlation of patient outcome to clinical factors, functional neuroimaging findings, and pathological characteristics and molecular studies of resected tissue. Methods. Tissue samples were collected in 21 patients. Coordinates from intraoperative tissue localization were downloaded from the IGS system and transformed into patient space, as defined by preoperative high-resolution T1-weighted MRI volume. Tissue landmarks in patient space were then transformed into MNI standard space for identification of the BAs of the tissue samples. Results. Anatomical locations of resected tissue were identified from the intraoperative resection landmarks. The BAs were identified for 17 of the 21 patients. The remaining patients had abnormal brain anatomy that could not be meaningfully coregistered with the MNI standard brain without causing extensive distortion. Conclusions. This coregistration and landmark tracking technique allows localization of tissue that is resected from patients with epilepsy and identification of the BAs for each resected region. The ability to perform tissue localization allows investigators to relate preoperative, intraoperative, and postoperative functional and anatomical brain imaging to better understand patient outcomes, improve patient safety, and aid in research.

Original languageEnglish (US)
Article numberE8
JournalNeurosurgical Focus
Volume34
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Epilepsy
Functional Neuroimaging
Brain
Anatomy
Patient Safety
Electrodes
Research Personnel
Research

Keywords

  • Epilepsy
  • Image coregistration
  • Imaging-guided surgery
  • Neuroimaging modality
  • Resective epilepsy surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Medicine(all)

Cite this

Poliachik, S. L., Poliakov, A. V., Jansen, L. A., McDaniel, S. S., Wray, C., Kuratani, J., ... Novotny, E. J. (2013). Tissue localization during resective epilepsy surgery. Neurosurgical Focus, 34(6), [E8]. https://doi.org/10.3171/2013.3.FOCUS1360

Tissue localization during resective epilepsy surgery. / Poliachik, Sandra L.; Poliakov, Andrew V.; Jansen, Laura A.; McDaniel, Sharon S.; Wray, Carter; Kuratani, John; Saneto, Russell P.; Ojemann, Jeffrey G.; Novotny, Edward J.

In: Neurosurgical Focus, Vol. 34, No. 6, E8, 06.2013.

Research output: Contribution to journalArticle

Poliachik, SL, Poliakov, AV, Jansen, LA, McDaniel, SS, Wray, C, Kuratani, J, Saneto, RP, Ojemann, JG & Novotny, EJ 2013, 'Tissue localization during resective epilepsy surgery', Neurosurgical Focus, vol. 34, no. 6, E8. https://doi.org/10.3171/2013.3.FOCUS1360
Poliachik SL, Poliakov AV, Jansen LA, McDaniel SS, Wray C, Kuratani J et al. Tissue localization during resective epilepsy surgery. Neurosurgical Focus. 2013 Jun;34(6). E8. https://doi.org/10.3171/2013.3.FOCUS1360
Poliachik, Sandra L. ; Poliakov, Andrew V. ; Jansen, Laura A. ; McDaniel, Sharon S. ; Wray, Carter ; Kuratani, John ; Saneto, Russell P. ; Ojemann, Jeffrey G. ; Novotny, Edward J. / Tissue localization during resective epilepsy surgery. In: Neurosurgical Focus. 2013 ; Vol. 34, No. 6.
@article{faa1a7572fcc4558bfe939635f1ef6a5,
title = "Tissue localization during resective epilepsy surgery",
abstract = "Object. Imaging-guided surgery (IGS) systems are widely used in neurosurgical practice. During epilepsy surgery, the authors routinely use IGS landmarks to localize intracranial electrodes and/or specific brain regions. The authors have developed a technique to coregister these landmarks with pre- and postoperative scans and the Montreal Neurological Institute (MNI) standard space brain MRI to allow 1) localization and identification of tissue anatomy; and 2) identification of Brodmann areas (BAs) of the tissue resected during epilepsy surgery. Tracking tissue in this fashion allows for better correlation of patient outcome to clinical factors, functional neuroimaging findings, and pathological characteristics and molecular studies of resected tissue. Methods. Tissue samples were collected in 21 patients. Coordinates from intraoperative tissue localization were downloaded from the IGS system and transformed into patient space, as defined by preoperative high-resolution T1-weighted MRI volume. Tissue landmarks in patient space were then transformed into MNI standard space for identification of the BAs of the tissue samples. Results. Anatomical locations of resected tissue were identified from the intraoperative resection landmarks. The BAs were identified for 17 of the 21 patients. The remaining patients had abnormal brain anatomy that could not be meaningfully coregistered with the MNI standard brain without causing extensive distortion. Conclusions. This coregistration and landmark tracking technique allows localization of tissue that is resected from patients with epilepsy and identification of the BAs for each resected region. The ability to perform tissue localization allows investigators to relate preoperative, intraoperative, and postoperative functional and anatomical brain imaging to better understand patient outcomes, improve patient safety, and aid in research.",
keywords = "Epilepsy, Image coregistration, Imaging-guided surgery, Neuroimaging modality, Resective epilepsy surgery",
author = "Poliachik, {Sandra L.} and Poliakov, {Andrew V.} and Jansen, {Laura A.} and McDaniel, {Sharon S.} and Carter Wray and John Kuratani and Saneto, {Russell P.} and Ojemann, {Jeffrey G.} and Novotny, {Edward J.}",
year = "2013",
month = "6",
doi = "10.3171/2013.3.FOCUS1360",
language = "English (US)",
volume = "34",
journal = "Neurosurgical Focus",
issn = "1092-0684",
publisher = "American Association of Neurological Surgeons",
number = "6",

}

TY - JOUR

T1 - Tissue localization during resective epilepsy surgery

AU - Poliachik, Sandra L.

AU - Poliakov, Andrew V.

AU - Jansen, Laura A.

AU - McDaniel, Sharon S.

AU - Wray, Carter

AU - Kuratani, John

AU - Saneto, Russell P.

AU - Ojemann, Jeffrey G.

AU - Novotny, Edward J.

PY - 2013/6

Y1 - 2013/6

N2 - Object. Imaging-guided surgery (IGS) systems are widely used in neurosurgical practice. During epilepsy surgery, the authors routinely use IGS landmarks to localize intracranial electrodes and/or specific brain regions. The authors have developed a technique to coregister these landmarks with pre- and postoperative scans and the Montreal Neurological Institute (MNI) standard space brain MRI to allow 1) localization and identification of tissue anatomy; and 2) identification of Brodmann areas (BAs) of the tissue resected during epilepsy surgery. Tracking tissue in this fashion allows for better correlation of patient outcome to clinical factors, functional neuroimaging findings, and pathological characteristics and molecular studies of resected tissue. Methods. Tissue samples were collected in 21 patients. Coordinates from intraoperative tissue localization were downloaded from the IGS system and transformed into patient space, as defined by preoperative high-resolution T1-weighted MRI volume. Tissue landmarks in patient space were then transformed into MNI standard space for identification of the BAs of the tissue samples. Results. Anatomical locations of resected tissue were identified from the intraoperative resection landmarks. The BAs were identified for 17 of the 21 patients. The remaining patients had abnormal brain anatomy that could not be meaningfully coregistered with the MNI standard brain without causing extensive distortion. Conclusions. This coregistration and landmark tracking technique allows localization of tissue that is resected from patients with epilepsy and identification of the BAs for each resected region. The ability to perform tissue localization allows investigators to relate preoperative, intraoperative, and postoperative functional and anatomical brain imaging to better understand patient outcomes, improve patient safety, and aid in research.

AB - Object. Imaging-guided surgery (IGS) systems are widely used in neurosurgical practice. During epilepsy surgery, the authors routinely use IGS landmarks to localize intracranial electrodes and/or specific brain regions. The authors have developed a technique to coregister these landmarks with pre- and postoperative scans and the Montreal Neurological Institute (MNI) standard space brain MRI to allow 1) localization and identification of tissue anatomy; and 2) identification of Brodmann areas (BAs) of the tissue resected during epilepsy surgery. Tracking tissue in this fashion allows for better correlation of patient outcome to clinical factors, functional neuroimaging findings, and pathological characteristics and molecular studies of resected tissue. Methods. Tissue samples were collected in 21 patients. Coordinates from intraoperative tissue localization were downloaded from the IGS system and transformed into patient space, as defined by preoperative high-resolution T1-weighted MRI volume. Tissue landmarks in patient space were then transformed into MNI standard space for identification of the BAs of the tissue samples. Results. Anatomical locations of resected tissue were identified from the intraoperative resection landmarks. The BAs were identified for 17 of the 21 patients. The remaining patients had abnormal brain anatomy that could not be meaningfully coregistered with the MNI standard brain without causing extensive distortion. Conclusions. This coregistration and landmark tracking technique allows localization of tissue that is resected from patients with epilepsy and identification of the BAs for each resected region. The ability to perform tissue localization allows investigators to relate preoperative, intraoperative, and postoperative functional and anatomical brain imaging to better understand patient outcomes, improve patient safety, and aid in research.

KW - Epilepsy

KW - Image coregistration

KW - Imaging-guided surgery

KW - Neuroimaging modality

KW - Resective epilepsy surgery

UR - http://www.scopus.com/inward/record.url?scp=84879089247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879089247&partnerID=8YFLogxK

U2 - 10.3171/2013.3.FOCUS1360

DO - 10.3171/2013.3.FOCUS1360

M3 - Article

C2 - 23724842

AN - SCOPUS:84879089247

VL - 34

JO - Neurosurgical Focus

JF - Neurosurgical Focus

SN - 1092-0684

IS - 6

M1 - E8

ER -