Tissue effects of saw palmetto and finasteride

Use of biopsy cores for in situ quantification of prostatic androgens

Leonard S. Marks, David Hess, Frederick J. Dorey, Maria Luz Macairan, Paul Bryan Cruz Santos, Varro E. Tyler

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Abstract

    Objectives. To determine the effects of a saw palmetto herbal blend (SPHB) compared with finasteride on prostatic tissue androgen levels and to evaluate needle biopsies as a source of tissue for such determinations. Methods. Prostate levels of testosterone and dihydrotestosterone (DHT) were measured on 5 to 10-mg biopsy specimens (18-gauge needle cores) in three groups of men with symptomatic benign prostatic hyperplasia: 15 men receiving chronic finasteride therapy versus 7 untreated controls; 4 men undergoing prostate adenomectomy to determine sampling variability (10 specimens each); and 40 men participating in a 6-month randomized trial of SPHB versus placebo, before and after treatment. Results. Prostatic tissue DHT levels were found to be several times higher than the levels of testosterone (5.01 versus 1.51 ng/g), that ratio becoming reversed (1.05 versus 3.63 ng/g) with chronic finasteride therapy. The finasteride effect was statistically significant for both androgens (P

    Original languageEnglish (US)
    Pages (from-to)999-1005
    Number of pages7
    JournalUrology
    Volume57
    Issue number5
    DOIs
    StatePublished - 2001

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    Finasteride
    Androgens
    Biopsy
    Dihydrotestosterone
    Testosterone
    Prostate
    Prostatic Hyperplasia
    Needle Biopsy
    Needles
    Therapeutics
    Placebos

    ASJC Scopus subject areas

    • Urology

    Cite this

    Marks, L. S., Hess, D., Dorey, F. J., Luz Macairan, M., Cruz Santos, P. B., & Tyler, V. E. (2001). Tissue effects of saw palmetto and finasteride: Use of biopsy cores for in situ quantification of prostatic androgens. Urology, 57(5), 999-1005. https://doi.org/10.1016/S0090-4295(00)01052-9

    Tissue effects of saw palmetto and finasteride : Use of biopsy cores for in situ quantification of prostatic androgens. / Marks, Leonard S.; Hess, David; Dorey, Frederick J.; Luz Macairan, Maria; Cruz Santos, Paul Bryan; Tyler, Varro E.

    In: Urology, Vol. 57, No. 5, 2001, p. 999-1005.

    Research output: Contribution to journalArticle

    Marks, LS, Hess, D, Dorey, FJ, Luz Macairan, M, Cruz Santos, PB & Tyler, VE 2001, 'Tissue effects of saw palmetto and finasteride: Use of biopsy cores for in situ quantification of prostatic androgens', Urology, vol. 57, no. 5, pp. 999-1005. https://doi.org/10.1016/S0090-4295(00)01052-9
    Marks, Leonard S. ; Hess, David ; Dorey, Frederick J. ; Luz Macairan, Maria ; Cruz Santos, Paul Bryan ; Tyler, Varro E. / Tissue effects of saw palmetto and finasteride : Use of biopsy cores for in situ quantification of prostatic androgens. In: Urology. 2001 ; Vol. 57, No. 5. pp. 999-1005.
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    T2 - Use of biopsy cores for in situ quantification of prostatic androgens

    AU - Marks, Leonard S.

    AU - Hess, David

    AU - Dorey, Frederick J.

    AU - Luz Macairan, Maria

    AU - Cruz Santos, Paul Bryan

    AU - Tyler, Varro E.

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    AB - Objectives. To determine the effects of a saw palmetto herbal blend (SPHB) compared with finasteride on prostatic tissue androgen levels and to evaluate needle biopsies as a source of tissue for such determinations. Methods. Prostate levels of testosterone and dihydrotestosterone (DHT) were measured on 5 to 10-mg biopsy specimens (18-gauge needle cores) in three groups of men with symptomatic benign prostatic hyperplasia: 15 men receiving chronic finasteride therapy versus 7 untreated controls; 4 men undergoing prostate adenomectomy to determine sampling variability (10 specimens each); and 40 men participating in a 6-month randomized trial of SPHB versus placebo, before and after treatment. Results. Prostatic tissue DHT levels were found to be several times higher than the levels of testosterone (5.01 versus 1.51 ng/g), that ratio becoming reversed (1.05 versus 3.63 ng/g) with chronic finasteride therapy. The finasteride effect was statistically significant for both androgens (P

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