Through the looking glass

    Research output: Contribution to journalComment/debate

    Abstract

    DNA methylation is a common mode of gene silencing in cancer, and MDS remains the poster child for a disease in which targeting the DNMT enzymes leads to clinical benefit. 1-4 However, some important questions remain unanswered, 2 of which are directly addressed in this issue of Blood by Figueroa and colleagues 5: What pivotal gene sets are silenced by DNA methylation in MDS and de novo AML, a question that begs a reference to the patterns of normal marrow cells on a genome-wide scale, and what global changes in DNA methylation can be achieved when treating patients with DNMT inhibitors?

    Original languageEnglish (US)
    Pages (from-to)3363-3364
    Number of pages2
    JournalBlood
    Volume114
    Issue number16
    DOIs
    StatePublished - Nov 19 2009

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    ASJC Scopus subject areas

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology

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