Through the looking glass

    Research output: Contribution to journalArticle

    Abstract

    DNA methylation is a common mode of gene silencing in cancer, and MDS remains the poster child for a disease in which targeting the DNMT enzymes leads to clinical benefit. 1-4 However, some important questions remain unanswered, 2 of which are directly addressed in this issue of Blood by Figueroa and colleagues 5: What pivotal gene sets are silenced by DNA methylation in MDS and de novo AML, a question that begs a reference to the patterns of normal marrow cells on a genome-wide scale, and what global changes in DNA methylation can be achieved when treating patients with DNMT inhibitors?

    Original languageEnglish (US)
    Pages (from-to)3363-3364
    Number of pages2
    JournalBlood
    Volume114
    Issue number16
    DOIs
    StatePublished - 2009

    Fingerprint

    DNA Methylation
    Glass
    Genes
    Posters
    Gene Silencing
    Blood
    Bone Marrow
    Cells
    Genome
    Enzymes
    Neoplasms

    ASJC Scopus subject areas

    • Hematology
    • Biochemistry
    • Cell Biology
    • Immunology

    Cite this

    Through the looking glass. / Alumkal, Joshi.

    In: Blood, Vol. 114, No. 16, 2009, p. 3363-3364.

    Research output: Contribution to journalArticle

    Alumkal, Joshi. / Through the looking glass. In: Blood. 2009 ; Vol. 114, No. 16. pp. 3363-3364.
    @article{7185a57932f1494e8e510e3bd84d1a87,
    title = "Through the looking glass",
    abstract = "DNA methylation is a common mode of gene silencing in cancer, and MDS remains the poster child for a disease in which targeting the DNMT enzymes leads to clinical benefit. 1-4 However, some important questions remain unanswered, 2 of which are directly addressed in this issue of Blood by Figueroa and colleagues 5: What pivotal gene sets are silenced by DNA methylation in MDS and de novo AML, a question that begs a reference to the patterns of normal marrow cells on a genome-wide scale, and what global changes in DNA methylation can be achieved when treating patients with DNMT inhibitors?",
    author = "Joshi Alumkal",
    year = "2009",
    doi = "10.1182/blood-2009-08-238162",
    language = "English (US)",
    volume = "114",
    pages = "3363--3364",
    journal = "Blood",
    issn = "0006-4971",
    publisher = "American Society of Hematology",
    number = "16",

    }

    TY - JOUR

    T1 - Through the looking glass

    AU - Alumkal, Joshi

    PY - 2009

    Y1 - 2009

    N2 - DNA methylation is a common mode of gene silencing in cancer, and MDS remains the poster child for a disease in which targeting the DNMT enzymes leads to clinical benefit. 1-4 However, some important questions remain unanswered, 2 of which are directly addressed in this issue of Blood by Figueroa and colleagues 5: What pivotal gene sets are silenced by DNA methylation in MDS and de novo AML, a question that begs a reference to the patterns of normal marrow cells on a genome-wide scale, and what global changes in DNA methylation can be achieved when treating patients with DNMT inhibitors?

    AB - DNA methylation is a common mode of gene silencing in cancer, and MDS remains the poster child for a disease in which targeting the DNMT enzymes leads to clinical benefit. 1-4 However, some important questions remain unanswered, 2 of which are directly addressed in this issue of Blood by Figueroa and colleagues 5: What pivotal gene sets are silenced by DNA methylation in MDS and de novo AML, a question that begs a reference to the patterns of normal marrow cells on a genome-wide scale, and what global changes in DNA methylation can be achieved when treating patients with DNMT inhibitors?

    UR - http://www.scopus.com/inward/record.url?scp=70449502133&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=70449502133&partnerID=8YFLogxK

    U2 - 10.1182/blood-2009-08-238162

    DO - 10.1182/blood-2009-08-238162

    M3 - Article

    C2 - 19833849

    AN - SCOPUS:70449502133

    VL - 114

    SP - 3363

    EP - 3364

    JO - Blood

    JF - Blood

    SN - 0006-4971

    IS - 16

    ER -