Three-dimensional reconstruction of the color doppler-imaged vena contracta for quantifying aortic regurgitation

Studies in a chronic animal model

Yoshiki Mori, Takahiro Shiota, Michael Jones, Suthep Wanitkun, Timothy Irvine, Xiaokui Li, Alain Delabays, Natesa G. Pandian, David Sahn

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background - The purpose of this study was to investigate the use of 3- dimensional (3D) reconstruction of color Doppler flow maps to image and extract the vena contracta cross-sectional area to determine the severity of aortic regurgitation (AR) in an animal model. Evaluation of the vena contracta with 2-dimensional imaging systems may not be sufficiently robust to fully characterize this region, which may be asymmetrically shaped. Methods and Results - In 6 sheep with surgically induced chronic AR, 18 hemodynamically different states were studied. Instantaneous regurgitant flow rates were obtained by aortic and pulmonary electromagnetic flowmeters (EMFs) as reference standards, and aortic regurgitant effective orifice areas (EOAs) were determined from EMF regurgitant flow rates divided by continuous-wave (CW) Doppler velocities. Composite video data for color Doppler imaging of the aortic regurgitant flows were transferred into a TomTec computer after computer-controlled 180°rotational acquisition. After the 3D data transverse to the flow jet were sectioned, the smallest proximal jet cross section was identified for direct measurement of the vena contracta area. Peak regurgitant flow rates and regurgitant stroke volumes were calculated as the product of these areas and the CW Doppler peak velocities and velocity- time integrals, respectively. There was an excellent correlation between the 3D-derived vena contracta areas and reference EOAs (r=0.99, SEE=0.01 cm2) and between 3D and reference peak regurgitant flow rates and regurgitant stroke volumes (r=0.99, difference=0.11 L/min; r=0.99, difference=1.5 mL/beat, respectively). Conclusions - 3D-based determination of the vena contracta cross-sectional area can provide accurate quantification of the severity of AR.

Original languageEnglish (US)
Pages (from-to)1611-1617
Number of pages7
JournalCirculation
Volume99
Issue number12
StatePublished - Mar 30 1999

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Aortic Valve Insufficiency
Flowmeters
Animal Models
Color
Electromagnetic Phenomena
Stroke Volume
Sheep
Lung

Keywords

  • Blood flow
  • Echocardiography
  • Imaging
  • Regurgitation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mori, Y., Shiota, T., Jones, M., Wanitkun, S., Irvine, T., Li, X., ... Sahn, D. (1999). Three-dimensional reconstruction of the color doppler-imaged vena contracta for quantifying aortic regurgitation: Studies in a chronic animal model. Circulation, 99(12), 1611-1617.

Three-dimensional reconstruction of the color doppler-imaged vena contracta for quantifying aortic regurgitation : Studies in a chronic animal model. / Mori, Yoshiki; Shiota, Takahiro; Jones, Michael; Wanitkun, Suthep; Irvine, Timothy; Li, Xiaokui; Delabays, Alain; Pandian, Natesa G.; Sahn, David.

In: Circulation, Vol. 99, No. 12, 30.03.1999, p. 1611-1617.

Research output: Contribution to journalArticle

Mori, Y, Shiota, T, Jones, M, Wanitkun, S, Irvine, T, Li, X, Delabays, A, Pandian, NG & Sahn, D 1999, 'Three-dimensional reconstruction of the color doppler-imaged vena contracta for quantifying aortic regurgitation: Studies in a chronic animal model', Circulation, vol. 99, no. 12, pp. 1611-1617.
Mori, Yoshiki ; Shiota, Takahiro ; Jones, Michael ; Wanitkun, Suthep ; Irvine, Timothy ; Li, Xiaokui ; Delabays, Alain ; Pandian, Natesa G. ; Sahn, David. / Three-dimensional reconstruction of the color doppler-imaged vena contracta for quantifying aortic regurgitation : Studies in a chronic animal model. In: Circulation. 1999 ; Vol. 99, No. 12. pp. 1611-1617.
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