Three-dimensional myocardial contrast echocardiography using Quantison Depot®, a new contrast agent: An experimental study with implications for the cardiac catheterization laboratory

Andre Linka, Gursel Ates, Soroosh Firoozan, Kevin Wei, Danny Skyba, Sanjiv Kaul

Research output: Contribution to journalArticle

Abstract

The aim of this study was to determine whether a new deposit agent (Quantison Depot®, Andaris, UK) would provide accurate information regarding risk area during coronary occlusion and infarct size after reperfusion when combined with 3-dimensional echocardiography (3DE). This agent is composed of air-filled albumin shells with a mean size of 10 μm which gets lodged within the microcirculation producing intense myocardial opacification. 3DE was performed with a Tomtec rotational device. Quantison Depot® (0.4 mg·kg-1) was injected into the left atrium of 8 dogs during coronary occlusion (when 99mTc as also injected for autoradiography) and 2-4 hours after reperfusion. The heart was breadloafed into 0.9 mm slices for the assessment of risk area by 99mTc autoradiography and infarct size by triphenyl tetrazolium chloride (TTC) tissue staining. Images corresponding to the heart slices were reconstructed from the 3DE data. From these images, risk and infarct volumes were calculated for all techniques. An excellent correlation was noted between 3DE and 99mTc autoradiography for assessment of risk volume (y=l. 02x + 1.1, r=0.89, p

Original languageEnglish (US)
Pages (from-to)414
Number of pages1
JournalJournal of the American Society of Echocardiography
Volume10
Issue number4
StatePublished - 1997
Externally publishedYes

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Cardiac Catheterization
Contrast Media
Echocardiography
Autoradiography
Coronary Occlusion
Reperfusion
Microcirculation
Heart Atria
Chlorides
Albumins
Air
Dogs
Staining and Labeling
Equipment and Supplies
Quantison Depot

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Three-dimensional myocardial contrast echocardiography using Quantison Depot{\circledR}, a new contrast agent: An experimental study with implications for the cardiac catheterization laboratory",
abstract = "The aim of this study was to determine whether a new deposit agent (Quantison Depot{\circledR}, Andaris, UK) would provide accurate information regarding risk area during coronary occlusion and infarct size after reperfusion when combined with 3-dimensional echocardiography (3DE). This agent is composed of air-filled albumin shells with a mean size of 10 μm which gets lodged within the microcirculation producing intense myocardial opacification. 3DE was performed with a Tomtec rotational device. Quantison Depot{\circledR} (0.4 mg·kg-1) was injected into the left atrium of 8 dogs during coronary occlusion (when 99mTc as also injected for autoradiography) and 2-4 hours after reperfusion. The heart was breadloafed into 0.9 mm slices for the assessment of risk area by 99mTc autoradiography and infarct size by triphenyl tetrazolium chloride (TTC) tissue staining. Images corresponding to the heart slices were reconstructed from the 3DE data. From these images, risk and infarct volumes were calculated for all techniques. An excellent correlation was noted between 3DE and 99mTc autoradiography for assessment of risk volume (y=l. 02x + 1.1, r=0.89, p",
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T1 - Three-dimensional myocardial contrast echocardiography using Quantison Depot®, a new contrast agent

T2 - An experimental study with implications for the cardiac catheterization laboratory

AU - Linka, Andre

AU - Ates, Gursel

AU - Firoozan, Soroosh

AU - Wei, Kevin

AU - Skyba, Danny

AU - Kaul, Sanjiv

PY - 1997

Y1 - 1997

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AB - The aim of this study was to determine whether a new deposit agent (Quantison Depot®, Andaris, UK) would provide accurate information regarding risk area during coronary occlusion and infarct size after reperfusion when combined with 3-dimensional echocardiography (3DE). This agent is composed of air-filled albumin shells with a mean size of 10 μm which gets lodged within the microcirculation producing intense myocardial opacification. 3DE was performed with a Tomtec rotational device. Quantison Depot® (0.4 mg·kg-1) was injected into the left atrium of 8 dogs during coronary occlusion (when 99mTc as also injected for autoradiography) and 2-4 hours after reperfusion. The heart was breadloafed into 0.9 mm slices for the assessment of risk area by 99mTc autoradiography and infarct size by triphenyl tetrazolium chloride (TTC) tissue staining. Images corresponding to the heart slices were reconstructed from the 3DE data. From these images, risk and infarct volumes were calculated for all techniques. An excellent correlation was noted between 3DE and 99mTc autoradiography for assessment of risk volume (y=l. 02x + 1.1, r=0.89, p

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