TY - CHAP
T1 - Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders
AU - Bhatti, J. S.
AU - Kumar, S.
AU - Vijayan, M.
AU - Bhatti, G. K.
AU - Reddy, P. H.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017
Y1 - 2017
N2 - Mitochondria are complex, intercellular organelles present in the cells and are involved in multiple roles including ATP formation, free radicals generation and scavenging, calcium homeostasis, cellular differentiation, and cell death. Many studies depicted the involvement of mitochondrial dysfunction and oxidative damage in aging and pathogenesis of age-related metabolic disorders and neurodegenerative diseases. Remarkable advancements have been made in understanding the structure, function, and physiology of mitochondria in metabolic disorders such as diabetes, obesity, cardiovascular diseases, and stroke. Further, much progress has been done in the improvement of therapeutic strategies, including lifestyle interventions, pharmacological, and mitochondria-targeted therapeutic approaches. These strategies were mainly focused to reduce the mitochondrial dysfunction caused by oxidative stress and to retain the mitochondrial health in various diseases. In this chapter, we have highlighted the involvement of mitochondrial dysfunction in the pathophysiology of various disorders and recent progress in the development of mitochondria-targeted molecules as therapeutic measures for metabolic disorders.
AB - Mitochondria are complex, intercellular organelles present in the cells and are involved in multiple roles including ATP formation, free radicals generation and scavenging, calcium homeostasis, cellular differentiation, and cell death. Many studies depicted the involvement of mitochondrial dysfunction and oxidative damage in aging and pathogenesis of age-related metabolic disorders and neurodegenerative diseases. Remarkable advancements have been made in understanding the structure, function, and physiology of mitochondria in metabolic disorders such as diabetes, obesity, cardiovascular diseases, and stroke. Further, much progress has been done in the improvement of therapeutic strategies, including lifestyle interventions, pharmacological, and mitochondria-targeted therapeutic approaches. These strategies were mainly focused to reduce the mitochondrial dysfunction caused by oxidative stress and to retain the mitochondrial health in various diseases. In this chapter, we have highlighted the involvement of mitochondrial dysfunction in the pathophysiology of various disorders and recent progress in the development of mitochondria-targeted molecules as therapeutic measures for metabolic disorders.
KW - Age-related metabolic disorders
KW - Cardiovascular disease
KW - Metabolic syndrome
KW - Mitochondria
KW - Mitochondria-targeted antioxidants
KW - Mitochondrial dysfunction
KW - Obesity
KW - Oxidative stress
KW - Reactive oxygen species
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85011078979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011078979&partnerID=8YFLogxK
U2 - 10.1016/bs.pmbts.2016.12.012
DO - 10.1016/bs.pmbts.2016.12.012
M3 - Chapter
C2 - 28253984
AN - SCOPUS:85011078979
T3 - Progress in Molecular Biology and Translational Science
SP - 13
EP - 46
BT - Progress in Molecular Biology and Translational Science
PB - Elsevier B.V.
ER -