@article{14400cbd9dfd4b278c1f7b61d65712a7,
title = "Theoretical Modeling of Coagulation Management with Therapeutic Plasma or Prothrombin Complex Concentrate",
abstract = "Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.",
author = "Herbert Sch{\"o}chl and Oliver Grottke and Ken Sutor and Kieron Dony and Martin Schreiber and Marco Ranucci and Collins, {Peter W.}",
note = "Funding Information: From the *Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Vienna, Austria; †Department of Anaesthesiology and Intensive Care, AUVA Trauma Centre, Salzburg, Austria; ‡Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany; §Meridian HealthComms Ltd, Plumley, Cheshire, United Kingdom; ‖Parker Design Consultants Ltd, Lostock Gralam, Cheshire, United Kingdom; ¶Trauma, Critical Care and Acute Care Surgery Division, Oregon Health and Science University, Portland, Oregon; #Department of Cardiothoracic and Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy; and **School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, United Kingdom. Accepted for publication July 6, 2017. Funding: Development of the electronic tool and medical writing were supported by CSL Behring. Contributions from K.S. and K.D. to the development of the electronic tools and the manuscript were funded by CSL Behring via Meridian HealthComms. Conflicts of Interest: See Disclosures at the end of the article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal{\textquoteright}s website (www.anesthesia-analgesia.org). Reprints will not be available from the authors. Funding Information: Conflicts of Interest: Herbert Sch{\"o}chl has received lecture fees and study support from the following companies: CSL Behring, Tem International, Boehringer Ingelheim, and Bayer Healthcare. Name: Oliver Grottke, MD. Contribution: This author helped advise regarding trauma, contributed to the assumptions on which the modeling was based, and reviewed it critically and approved the final version. Conflicts of Interest: Oliver Grottke received research funding from Bayer, Biotest, Boehringer Ingelheim, CSL Behring, Novo Nordisk, and Nycomed. He has also received honoraria for lectures and consultancy from Baxalta, Bayer Healthcare, Boehringer Ingelheim, CSL Behring, Octapharma, Pfizer, Portola, and Sanofi. Name: Ken Sutor, BSc. Contribution: This author helped develop the mathematical formulae and coding for the electronic tool, draft the manuscript, contributed to the assumptions on which the modeling was based, and reviewed it critically and approved the final version. Conflicts of Interest: None. Name: Kieron Dony, HND. Contribution: This author helped develop the mathematical formulae and coding for the electronic tool, contributed to the assumptions on which the modeling was based, and reviewed it critically and approved the final version. Conflicts of Interest: None. Name: Martin Schreiber, MD. Contribution: This author helped advise regarding trauma, contributed to the assumptions on which the modeling was based, and reviewed it critically and approved the final version. Conflicts of Interest: Martin Schreiber serves as a consultant for CSL Behring and Velico Medical. Name: Marco Ranucci, MD. Contribution: This author helped provide expertise relating to cardiovascular surgery, contributed to the assumptions on which the modeling was based, and reviewed it critically and approved the final version. Conflicts of Interest: Marco Ranucci has received honoraria and/ or research support from CSL Behring, Grifols SA, Medtronic, Novo Nordisk, and Roche. Name: Peter W. Collins, MD. Contribution: This author helped provide clinical input regarding postpartum hemorrhage, contributed to the assumptions on which the modeling was based, and reviewed it critically and approved the final version. Funding Information: Conflicts of Interest: Peter W. Collins received honoraria for talks and research funding from CSL Behring and research support from Tem International. This manuscript was handled by: Roman M. Sniecinski, MD.",
year = "2017",
month = nov,
day = "1",
doi = "10.1213/ANE.0000000000002410",
language = "English (US)",
volume = "125",
pages = "1471--1474",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "5",
}