Abstract
Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1471-1474 |
| Number of pages | 4 |
| Journal | Anesthesia and Analgesia |
| Volume | 125 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1 2017 |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Theoretical Modeling of Coagulation Management with Therapeutic Plasma or Prothrombin Complex Concentrate. / Schöchl, Herbert; Grottke, Oliver; Sutor, Ken; Dony, Kieron; Schreiber, Martin; Ranucci, Marco; Collins, Peter W.
In: Anesthesia and Analgesia, Vol. 125, No. 5, 01.11.2017, p. 1471-1474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Theoretical Modeling of Coagulation Management with Therapeutic Plasma or Prothrombin Complex Concentrate
AU - Schöchl, Herbert
AU - Grottke, Oliver
AU - Sutor, Ken
AU - Dony, Kieron
AU - Schreiber, Martin
AU - Ranucci, Marco
AU - Collins, Peter W.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.
AB - Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.
UR - http://www.scopus.com/inward/record.url?scp=85032436246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032436246&partnerID=8YFLogxK
U2 - 10.1213/ANE.0000000000002410
DO - 10.1213/ANE.0000000000002410
M3 - Article
C2 - 28857856
AN - SCOPUS:85032436246
VL - 125
SP - 1471
EP - 1474
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 5
ER -