The use of d-amphetamine pellet implantation as a model for d-amphetamine tolerance in the mouse

Robert Hitzemann, H. H. Loh, F. B. Craves, E. F. Domino

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The use of d-amphetamine pellet implantation as a method for producing rapid central drug tolerance was investigated. Mice were implanted with d-amphetamine pellets containing 2 mg of drug and were challenged 24 h later, a time when no detectable drug was present, with various doses of d-amphetamine i.p. Implantation was found to potentiate the stereotyped activity and produced tolerance to the exploratory activity induced by d-amphetamine. Daily pellet implantation for 3 days was not found to produce tolerance to the stereotyped activities. Animals administered a single pellet showed no difference in the brain disposition or metabolism of a subsequent dose of 3H-d-amphetamine. Twenty-four hour pellet implantation markedly increased the rate of conversion of 3H-tyrosine to 3H-dopamine (330%) and 3H-norepinephrine (61%) in the subcortex. However, this effect was reversed by the administration of 10 mg/kg of d-amphetamine.

Original languageEnglish (US)
Pages (from-to)227-240
Number of pages14
JournalPsychopharmacologia
Volume30
Issue number3
DOIs
StatePublished - Sep 1973
Externally publishedYes

Fingerprint

Dextroamphetamine
Central Tolerance
Drug Tolerance
Pharmaceutical Preparations
Tyrosine
Dopamine
Norepinephrine
Brain

Keywords

  • Activity
  • Catecholamines
  • d-Amphetamine
  • Exploratory Activity
  • Implantation
  • Locomotor
  • Pellet
  • Tolerance

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

The use of d-amphetamine pellet implantation as a model for d-amphetamine tolerance in the mouse. / Hitzemann, Robert; Loh, H. H.; Craves, F. B.; Domino, E. F.

In: Psychopharmacologia, Vol. 30, No. 3, 09.1973, p. 227-240.

Research output: Contribution to journalArticle

Hitzemann, Robert ; Loh, H. H. ; Craves, F. B. ; Domino, E. F. / The use of d-amphetamine pellet implantation as a model for d-amphetamine tolerance in the mouse. In: Psychopharmacologia. 1973 ; Vol. 30, No. 3. pp. 227-240.
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