The use of biologics for uveitis associated with spondyloarthritis

Sruthi Arepalli, James (Jim) Rosenbaum

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

PURPOSE OF REVIEW: The term spondyloarthritis (SpA) encompasses a group of chronic inflammatory disorders of the joints, including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, inflammatory bowel disease, juvenile SpA and undifferentiated SpA. These diseases can also present with uveitis, or intraocular inflammation, which can be controlled with biologics. RECENT FINDINGS: Profound success has occurred with the tumor necrosis factor-α inhibitors infliximab and adalimumab, moderate success with certolizumab pegol and golimumab and less encouraging results with etanercept. Promising results have also been demonstrated with interleukin-17 (IL-17) antagonists, such as secukinumab ixekizumab or combined IL-12 and 23 medications, such as ustekinumab. SUMMARY: In cases of uveitis that require long-term control, biologics are an emerging and valuable class of medications for these patients, and may provide avenues to control both their underlying SpA and uveitis manifestations.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalCurrent opinion in rheumatology
Volume31
Issue number4
DOIs
StatePublished - Jul 1 2019

ASJC Scopus subject areas

  • Rheumatology

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