@article{eba36db8af2d47c18ddb0a1ef952cc74,
title = "The Toxicology Investigators Consortium Case Registry—the 2016 Experience",
abstract = "The Toxicology Investigators Consortium (ToxIC) Case Registry was established by the American College of Medical Toxicology in 2010. The Registry contains data from participating sites with the agreement that all bedside medical toxicology consultations will be entered. Currently, 83% of accredited medical toxicology fellowship programs in the USA participate. The Registry continues to grow each year, and as of 31 December 2016, a new milestone was reached, with more than 50,000 cases reported since its inception. The objective of this seventh annual report is to summarize the Registry{\textquoteright}s 2016 data and activity with its additional 8529 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from 1 January to 31 December 2016. Detailed data was collected from these cases and aggregated to provide information which includes the following: demographics (age, gender, race, ethnicity, HIV status), reason for medical toxicology evaluation (intentional pharmaceutical exposure, envenomation, withdrawal from a substance), agent and agent class, clinical signs and symptoms (vital sign abnormalities, organ system dysfunction), treatments and antidotes administered, fatality and life support withdrawal data. Fifty percent of cases involved females, and adults aged 19–65 were the most commonly reported. There were 86 patients (1.0%) with HIV-positive status known. Non-opioid analgesics were the most commonly reported agent class, with acetaminophen the most common agent reported. There were 126 fatalities reported in 2016 (1.5% of cases). Major trends in demographics and exposure characteristics remained similar overall with past years{\textquoteright} reports. While treatment interventions were commonly required, fatalities were rare.",
keywords = "Epidemiology, Medical toxicology, Overdose, Poisonings",
author = "{On behalf of the Toxicology Investigators Consortium Study Group} and Farrugia, {Lynn A.} and Rhyee, {Sean H.} and Calello, {Diane P.} and Campleman, {Sharan L.} and Riederer, {Anne M.} and Malashock, {Hannah R.} and Anthony Pizon and Timothy Wiegand and Wax, {Paul M.} and Jeffrey Brent and Aks, {S. E.} and Algren, {D. A.} and D. Alwasiyah and G. Beauchamp and Y. Bentur and Beuhler, {M. C.} and Boyle, {K. L.} and Bruccoleri, {R. E.} and Burns, {M. M.} and A. Cahana and Cannon, {R. D.} and Caravati, {E. M.} and Carey, {J. L.} and N. Chhabra and J. Chomin and Christian, {M. R.} and K. Conner and Cook, {M. D.} and Cumpston, {K. L.} and V. Dissanayake and Dribben, {W. H.} and Eisenga, {B. H.} and Engebretsen, {K. M.} and D. Falkowitz and A. Farkas and A. Fenton and Froberg, {B. A.} and Furmaga, {J. F.} and M. Ganetsky and F. Garlich and Geib, {A. J.} and R. Gorodetsky and S. Greene and Greller, {H. A.} and Gummin, {D. D.} and K. Hart and Hendrickson, {R. G.} and S. Hernandez and Hoyte, {C. O.} and S. Kusin",
note = "Funding Information: Toxicology Investigators Consortium (ToxIC) Study Group Collaborators: Aks SE, Algren DA, Alwasiyah D, Beauchamp G, Bentur Y, Beuhler MC, Boyle KL, Bruccoleri RE, Burns, MM, Cahana A, Cannon RD, Caravati EM, Carey JL, Chhabra N, Chomin J, Christian MR, Conner K, Cook MD, Cumpston KL, Dissanayake V, Dribben WH, Eisenga BH, Engebretsen KM, Falkowitz D, Farkas A, Fenton A, Froberg BA, Furmaga JF, Ganetsky M, Garlich F, Geib AJ, Gorodetsky R, Greene S, Greller HA, Gummin DD, Hart K, Hendrickson RG, Hernandez S, Hoyte CO, Judge BS, Kazzi Z, Kerns W, Kessler BD, King J, Kirschner R, Kleinschmidt KC, Kostic MA, Kusin S, Leikin, JB,LeRoy JM, Levine M, Lo CY, Lowry JA, Lung D, Lurie Y, Maddry J, Majlesi N, Manini AF, Marlin MB, McKay C, McKeever RG, McKeown NJ, Meggs WJ, Miller SN, Minns A, Moore E, Morgan BW, Mullins ME, Nappe TM, Nogar JN, Oakley E, Olmedo R, Othong R, Parker-Cote J,Regina A, Riley BD, Rowden A, Ruha AM, Rusyniak DE, Schult, R, Schwarz ES, Seifert SA, Sessions D, Shulman J, Smolinske SC, Smollin C, Spyres MB, Steck A, Stellpflug SJ, Sullivan R, Toce MS, Troendle MM, Vearrier D, Warrick BJ, Watts DC, Wills BK, Wolk BJ, Zosel AE. We also wish to thank study coordinators AB Adefeso, Mary Connie Aubin, Anita Kurt, Julie Licata, Misti Marshall, Maureen Morgan, Tammy Phan, Andrea Ramirez, and Melissa VandenBerg. ToxIC was supported by a continuation of a grant from the US National Institutes of Health on cardiovascular drug toxicity, a new contract with the US Food and Drug Administration, and the continuation of unrestricted grant support from BTG International, which was used to support the North American Snakebite Registry.",
year = "2017",
month = aug,
day = "1",
doi = "10.1007/s13181-017-0627-3",
language = "English (US)",
volume = "13",
pages = "203--226",
journal = "Journal of Medical Toxicology",
issn = "1556-9039",
publisher = "Springer New York",
number = "3",
}