The tiers and dimensions of evasion of the type i interferon response by human cytomegalovirus

Lisi Amsler, Marieke C. Verweij, Victor R. Defilippis

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Human cytomegalovirus (HCMV) is a member of the β-herpesvirus family that invariably occupies hosts for life despite a consistent multi-pronged antiviral immune response that targets the infection. This persistence is enabled by the large viral genome that encodes factors conferring a wide assortment of sophisticated, often redundant phenotypes that disable or otherwise manipulate impactful immune effector processes. The type I interferon system represents a first line of host defense against infecting viruses. The physiological reactions induced by secreted interferon act to effectively block replication of a broad spectrum of virus types, including HCMV. As such, the virus must exhibit counteractive mechanisms to these responses that involve their inhibition, tolerance, or re-purposing. The goal of this review is to describe the impact of the type I interferon system on HCMV replication and to showcase the number and diversity of strategies employed by the virus that allow infection of hosts in the presence of interferon-dependent activity.

Original languageEnglish (US)
Pages (from-to)4857-4871
Number of pages15
JournalJournal of molecular biology
Volume425
Issue number24
DOIs
StatePublished - Dec 13 2013

Keywords

  • cytomegalovirus
  • immune evasion
  • innate immunity
  • interferon

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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