The Swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila

Doris Kretzschmar, Gaiti Hasan, Sugandha Sharma, Martin Heisenberg, Seymour Benzer

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Swiss cheese (sws) mutant flies develop normally during larval life but show age-dependent neurodegeneration in the pupa and adult and have reduced life span. In late pupae, glial processes form abnormal, multilayered wrappings around neurons and axons. Degeneration first becomes evident in young flies as apoptosis in single scattered cells in the CNS, but later it becomes severe and widespread. In the adult, the number of glial wrappings increases with age. The sws gene is expressed in neurons in the brain cortex. The conceptual 1425 amino acid protein shows two domains with homology to the regulatory subunits of protein kinase A and to conceptual proteins of yet unknown function in yeast, worm, and human. Sequencing of two sws alleles shows amino acid substitutions in these two conserved domains. It is suggested that the novel SWS protein plays a role in a signaling mechanism between neurons and glia that regulates glial wrapping during development of the adult brain.

Original languageEnglish (US)
Pages (from-to)7425-7432
Number of pages8
JournalJournal of Neuroscience
Volume17
Issue number19
StatePublished - 1997
Externally publishedYes

Fingerprint

Cheese
Neuroglia
Drosophila
Pupa
Brain
Neurons
Diptera
Proteins
Amino Acid Substitution
Cyclic AMP-Dependent Protein Kinases
Axons
Yeasts
Alleles
Apoptosis
Amino Acids
Genes

Keywords

  • Adult central nervous system
  • Apoptosis
  • Drosophila
  • Gila-neuron interaction
  • Neurodegeneration
  • Reduced life span

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kretzschmar, D., Hasan, G., Sharma, S., Heisenberg, M., & Benzer, S. (1997). The Swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. Journal of Neuroscience, 17(19), 7425-7432.

The Swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. / Kretzschmar, Doris; Hasan, Gaiti; Sharma, Sugandha; Heisenberg, Martin; Benzer, Seymour.

In: Journal of Neuroscience, Vol. 17, No. 19, 1997, p. 7425-7432.

Research output: Contribution to journalArticle

Kretzschmar, D, Hasan, G, Sharma, S, Heisenberg, M & Benzer, S 1997, 'The Swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila', Journal of Neuroscience, vol. 17, no. 19, pp. 7425-7432.
Kretzschmar, Doris ; Hasan, Gaiti ; Sharma, Sugandha ; Heisenberg, Martin ; Benzer, Seymour. / The Swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. In: Journal of Neuroscience. 1997 ; Vol. 17, No. 19. pp. 7425-7432.
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