The sheep as a model of brain injury in the premature infant

Stephen Back, Art Riddle, Alan (Roger) Hohimer

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Preterm fetal sheep preparations provide unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in preparations that offer a number of significant advantages to model key aspects of human preterm cerebral injury. We describe a global cerebral ischemia preparation that replicates major features of acute and chronic human cerebral injury and which has provided access to complex clinically relevant studies of cerebral blood flow and neuro-imaging that are not feasible in smaller laboratory animals. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they allow an integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Pages107-128
Number of pages22
Volume104
DOIs
StatePublished - Sep 22 2015
Externally publishedYes

Publication series

NameNeuromethods
Volume104
ISSN (Print)08932336
ISSN (Electronic)19406045

Fingerprint

Premature Infants
Brain Injuries
Brain
Sheep
Neuroimaging
Wounds and Injuries
Cerebrovascular Circulation
Animals
Blood
Laboratory Animals
Brain Ischemia
Costs
Spectrum Analysis
Costs and Cost Analysis

Keywords

  • Apoptosis
  • Cerebral blood flow
  • Hypoxia-ischemia
  • MRI
  • Necrosis
  • Oligodendrocyte
  • White matter injury

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Back, S., Riddle, A., & Hohimer, A. R. (2015). The sheep as a model of brain injury in the premature infant. In Neuromethods (Vol. 104, pp. 107-128). (Neuromethods; Vol. 104). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-2709-8_8

The sheep as a model of brain injury in the premature infant. / Back, Stephen; Riddle, Art; Hohimer, Alan (Roger).

Neuromethods. Vol. 104 Humana Press Inc., 2015. p. 107-128 (Neuromethods; Vol. 104).

Research output: Chapter in Book/Report/Conference proceedingChapter

Back, S, Riddle, A & Hohimer, AR 2015, The sheep as a model of brain injury in the premature infant. in Neuromethods. vol. 104, Neuromethods, vol. 104, Humana Press Inc., pp. 107-128. https://doi.org/10.1007/978-1-4939-2709-8_8
Back S, Riddle A, Hohimer AR. The sheep as a model of brain injury in the premature infant. In Neuromethods. Vol. 104. Humana Press Inc. 2015. p. 107-128. (Neuromethods). https://doi.org/10.1007/978-1-4939-2709-8_8
Back, Stephen ; Riddle, Art ; Hohimer, Alan (Roger). / The sheep as a model of brain injury in the premature infant. Neuromethods. Vol. 104 Humana Press Inc., 2015. pp. 107-128 (Neuromethods).
@inbook{1f9a0cac45664020afb9d561c86948db,
title = "The sheep as a model of brain injury in the premature infant",
abstract = "Preterm fetal sheep preparations provide unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in preparations that offer a number of significant advantages to model key aspects of human preterm cerebral injury. We describe a global cerebral ischemia preparation that replicates major features of acute and chronic human cerebral injury and which has provided access to complex clinically relevant studies of cerebral blood flow and neuro-imaging that are not feasible in smaller laboratory animals. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they allow an integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.",
keywords = "Apoptosis, Cerebral blood flow, Hypoxia-ischemia, MRI, Necrosis, Oligodendrocyte, White matter injury",
author = "Stephen Back and Art Riddle and Hohimer, {Alan (Roger)}",
year = "2015",
month = "9",
day = "22",
doi = "10.1007/978-1-4939-2709-8_8",
language = "English (US)",
volume = "104",
series = "Neuromethods",
publisher = "Humana Press Inc.",
pages = "107--128",
booktitle = "Neuromethods",

}

TY - CHAP

T1 - The sheep as a model of brain injury in the premature infant

AU - Back, Stephen

AU - Riddle, Art

AU - Hohimer, Alan (Roger)

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Preterm fetal sheep preparations provide unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in preparations that offer a number of significant advantages to model key aspects of human preterm cerebral injury. We describe a global cerebral ischemia preparation that replicates major features of acute and chronic human cerebral injury and which has provided access to complex clinically relevant studies of cerebral blood flow and neuro-imaging that are not feasible in smaller laboratory animals. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they allow an integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.

AB - Preterm fetal sheep preparations provide unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in preparations that offer a number of significant advantages to model key aspects of human preterm cerebral injury. We describe a global cerebral ischemia preparation that replicates major features of acute and chronic human cerebral injury and which has provided access to complex clinically relevant studies of cerebral blood flow and neuro-imaging that are not feasible in smaller laboratory animals. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they allow an integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.

KW - Apoptosis

KW - Cerebral blood flow

KW - Hypoxia-ischemia

KW - MRI

KW - Necrosis

KW - Oligodendrocyte

KW - White matter injury

UR - http://www.scopus.com/inward/record.url?scp=84942115744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942115744&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-2709-8_8

DO - 10.1007/978-1-4939-2709-8_8

M3 - Chapter

AN - SCOPUS:84942115744

VL - 104

T3 - Neuromethods

SP - 107

EP - 128

BT - Neuromethods

PB - Humana Press Inc.

ER -