The roles and regulation of multicellular rosette structures during morphogenesis

Molly J. Harding, Hillary F. McGraw, Alex Nechiporuk

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Multicellular rosettes have recently been appreciated as important cellular intermediates that are observed during the formation of diverse organ systems. These rosettes are polarized, transient epithelial structures that sometimes recapitulate the form of the adult organ. Rosette formation has been studied in various developmental contexts, such as in the zebrafish lateral line primordium, the vertebrate pancreas, the Drosophila epithelium and retina, as well as in the adult neural stem cell niche. These studies have revealed that the cytoskeletal rearrangements responsible for rosette formation appear to be conserved. By contrast, the extracellular cues that trigger these rearrangements in vivo are less well understood and are more diverse. Here, we review recent studies of the genetic regulation and cellular transitions involved in rosette formation. We discuss and compare specific models for rosette formation and highlight outstanding questions in the field.

Original languageEnglish (US)
Pages (from-to)2549-2558
Number of pages10
JournalDevelopment (Cambridge)
Volume141
Issue number13
DOIs
StatePublished - 2014

Fingerprint

Rosette Formation
Morphogenesis
Stem Cell Niche
Adult Stem Cells
Neural Stem Cells
Zebrafish
Drosophila
Cues
Vertebrates
Retina
Pancreas
Epithelium

Keywords

  • Drosophila epithelium
  • Morphogenesis
  • Myosin II
  • Rosette
  • Zebrafish lateral line

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology

Cite this

The roles and regulation of multicellular rosette structures during morphogenesis. / Harding, Molly J.; McGraw, Hillary F.; Nechiporuk, Alex.

In: Development (Cambridge), Vol. 141, No. 13, 2014, p. 2549-2558.

Research output: Contribution to journalArticle

Harding, Molly J. ; McGraw, Hillary F. ; Nechiporuk, Alex. / The roles and regulation of multicellular rosette structures during morphogenesis. In: Development (Cambridge). 2014 ; Vol. 141, No. 13. pp. 2549-2558.
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