The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease

Thomas Jansson, Leslie Myatt, Theresa L. Powell

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Intrauterine growth restriction (IUGR) and fetal overgrowth occur in 15% of all pregnancies and lead to the delivery of a baby with an abnormally low or high birth weight, respectively. Both these conditions of pathological fetal growth increase the risk for perinatal complications and predispose the baby for the development of cardiovascular disease and diabetes in childhood and later in life. Fetal growth is closely related to the capacity of the placenta to transport nutrients and ions, which is dependent of the expression and activity of specific transporter proteins in the plasma membrane of the syncytiotrophoblast, the transporting epithelium of the human placenta. In human IUGR, some trophoblast nutrient and ion transporters are down regulated, whereas fetal overgrowth is associated with an up-regulation of transporters for amino acids and glucose in the placental barrier. Experimental studies have provided evidence to suggest that these changes in placental transport capacity constitute a direct cause of altered fetal growth. Therefore, regulation of placental nutrient transporters play a critical role in determining fetal growth and development, as well as the future health of the baby. This review is focused on the human and (i) summarizes the evidence that changes in the activity and expression of trophoblast nutrient and ion transporters play a central role in determining fetal growth, (ii) discusses the molecular mechanisms regulating trophoblast transporters, and (iii) highlights the implications of these findings for the development of pregnancy complications and fetal programming of cardiovascular and metabolic disease.

Original languageEnglish (US)
Pages (from-to)521-533
Number of pages13
JournalCurrent Vascular Pharmacology
Volume7
Issue number4
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Pregnancy Complications
Trophoblasts
Fetal Development
Ions
Food
Placenta
Cardiovascular Diseases
Amino Acid Transport Systems
Metabolic Diseases
Ion Transport
Growth and Development
Birth Weight
Up-Regulation
Epithelium
Cell Membrane
Glucose
Pregnancy
Growth

Keywords

  • Amino acids
  • Fetal development
  • Fetal growth
  • Maternal-fetal exchange
  • Nutrition
  • Placenta
  • Pregnancy
  • Transport

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease. / Jansson, Thomas; Myatt, Leslie; Powell, Theresa L.

In: Current Vascular Pharmacology, Vol. 7, No. 4, 2009, p. 521-533.

Research output: Contribution to journalArticle

@article{cdd34addb5aa4e25adfb092bd792ea3e,
title = "The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease",
abstract = "Intrauterine growth restriction (IUGR) and fetal overgrowth occur in 15{\%} of all pregnancies and lead to the delivery of a baby with an abnormally low or high birth weight, respectively. Both these conditions of pathological fetal growth increase the risk for perinatal complications and predispose the baby for the development of cardiovascular disease and diabetes in childhood and later in life. Fetal growth is closely related to the capacity of the placenta to transport nutrients and ions, which is dependent of the expression and activity of specific transporter proteins in the plasma membrane of the syncytiotrophoblast, the transporting epithelium of the human placenta. In human IUGR, some trophoblast nutrient and ion transporters are down regulated, whereas fetal overgrowth is associated with an up-regulation of transporters for amino acids and glucose in the placental barrier. Experimental studies have provided evidence to suggest that these changes in placental transport capacity constitute a direct cause of altered fetal growth. Therefore, regulation of placental nutrient transporters play a critical role in determining fetal growth and development, as well as the future health of the baby. This review is focused on the human and (i) summarizes the evidence that changes in the activity and expression of trophoblast nutrient and ion transporters play a central role in determining fetal growth, (ii) discusses the molecular mechanisms regulating trophoblast transporters, and (iii) highlights the implications of these findings for the development of pregnancy complications and fetal programming of cardiovascular and metabolic disease.",
keywords = "Amino acids, Fetal development, Fetal growth, Maternal-fetal exchange, Nutrition, Placenta, Pregnancy, Transport",
author = "Thomas Jansson and Leslie Myatt and Powell, {Theresa L.}",
year = "2009",
doi = "10.2174/157016109789043982",
language = "English (US)",
volume = "7",
pages = "521--533",
journal = "Current Vascular Pharmacology",
issn = "1570-1611",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease

AU - Jansson, Thomas

AU - Myatt, Leslie

AU - Powell, Theresa L.

PY - 2009

Y1 - 2009

N2 - Intrauterine growth restriction (IUGR) and fetal overgrowth occur in 15% of all pregnancies and lead to the delivery of a baby with an abnormally low or high birth weight, respectively. Both these conditions of pathological fetal growth increase the risk for perinatal complications and predispose the baby for the development of cardiovascular disease and diabetes in childhood and later in life. Fetal growth is closely related to the capacity of the placenta to transport nutrients and ions, which is dependent of the expression and activity of specific transporter proteins in the plasma membrane of the syncytiotrophoblast, the transporting epithelium of the human placenta. In human IUGR, some trophoblast nutrient and ion transporters are down regulated, whereas fetal overgrowth is associated with an up-regulation of transporters for amino acids and glucose in the placental barrier. Experimental studies have provided evidence to suggest that these changes in placental transport capacity constitute a direct cause of altered fetal growth. Therefore, regulation of placental nutrient transporters play a critical role in determining fetal growth and development, as well as the future health of the baby. This review is focused on the human and (i) summarizes the evidence that changes in the activity and expression of trophoblast nutrient and ion transporters play a central role in determining fetal growth, (ii) discusses the molecular mechanisms regulating trophoblast transporters, and (iii) highlights the implications of these findings for the development of pregnancy complications and fetal programming of cardiovascular and metabolic disease.

AB - Intrauterine growth restriction (IUGR) and fetal overgrowth occur in 15% of all pregnancies and lead to the delivery of a baby with an abnormally low or high birth weight, respectively. Both these conditions of pathological fetal growth increase the risk for perinatal complications and predispose the baby for the development of cardiovascular disease and diabetes in childhood and later in life. Fetal growth is closely related to the capacity of the placenta to transport nutrients and ions, which is dependent of the expression and activity of specific transporter proteins in the plasma membrane of the syncytiotrophoblast, the transporting epithelium of the human placenta. In human IUGR, some trophoblast nutrient and ion transporters are down regulated, whereas fetal overgrowth is associated with an up-regulation of transporters for amino acids and glucose in the placental barrier. Experimental studies have provided evidence to suggest that these changes in placental transport capacity constitute a direct cause of altered fetal growth. Therefore, regulation of placental nutrient transporters play a critical role in determining fetal growth and development, as well as the future health of the baby. This review is focused on the human and (i) summarizes the evidence that changes in the activity and expression of trophoblast nutrient and ion transporters play a central role in determining fetal growth, (ii) discusses the molecular mechanisms regulating trophoblast transporters, and (iii) highlights the implications of these findings for the development of pregnancy complications and fetal programming of cardiovascular and metabolic disease.

KW - Amino acids

KW - Fetal development

KW - Fetal growth

KW - Maternal-fetal exchange

KW - Nutrition

KW - Placenta

KW - Pregnancy

KW - Transport

UR - http://www.scopus.com/inward/record.url?scp=69549089015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69549089015&partnerID=8YFLogxK

U2 - 10.2174/157016109789043982

DO - 10.2174/157016109789043982

M3 - Article

VL - 7

SP - 521

EP - 533

JO - Current Vascular Pharmacology

JF - Current Vascular Pharmacology

SN - 1570-1611

IS - 4

ER -