The role of the tyrosine kinase inhibitor STI571 in the treatment of cancer

Michael E. O'Dwyer, Brian J. Druker

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The tyrosine kinase inhibitor STI571 exemplifies the successful development of a rationally designed, molecularly targeted therapy for the treatment of cancer. This review details the steps in the development of this agent and highlights why this drug has been so successful in the treatment of chronic myelogenous leukaemia. Future directions including the mechanisms and management of resistance and new therapeutic strategies are discussed. Finally, the literature supporting the use of STI571 in other malignancies, including solid tumors is briefly reviewed.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalCurrent Cancer Drug Targets
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2001

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ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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