The role of synaptic microRNAs in Alzheimer's disease

Subodh Kumar, P. Hemachandra Reddy

    Research output: Contribution to journalReview article

    Abstract

    Structurally and functionally active synapses are essential for neurotransmission and for maintaining normal synaptic and cognitive functions. Researchers have found that synaptic dysfunction is associated with the onset and progression of neurodegenerative diseases, such as Alzheimer's disease (AD), and synaptic dysfunction is even one of the main physiological hallmarks of AD. MiRNAs are present in small, subcellular compartments of the neuron such as neural dendrites, synaptic vesicles, and synaptosomes are known as synaptic miRNAs. Synaptic miRNAs involved in governing multiple synaptic functions that lead to healthy brain functioning and synaptic activity. However, the precise role of synaptic miRNAs has not been determined in AD progression. This review emphasizes the presence of miRNAs at the synapse, synaptic compartments and roles of miRNAs in multiple synaptic functions. We focused on synaptic miRNAs alteration in AD, and how the modulation of miRNAs effect the synaptic functions in AD. We also discussed the impact of synaptic miRNAs in AD progression concerning the synaptic ATP production, mitochondrial function, and synaptic activity.

    Original languageEnglish (US)
    Article number165937
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    Volume1866
    Issue number12
    DOIs
    StatePublished - Dec 1 2020

    Keywords

    • Alzheimer's disease
    • MicroRNAs
    • Synapse
    • Synaptic activity
    • Synaptosome

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology

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