Abstract
Stromelysin-1 was one of the first proteinases found to be associated with cancer. In this review we describe the role of stromelysin-1 in normal mammary gland involution. When stromelysin-1 is overexpressed in transgenic mice the mammary gland undergoes precocious involution and is predisposed to forming a reactive stroma resembling that of a wound site or a tumor. Stromelysin-1 may act as an oncogene because transgenic mice expressing an active form of the enzyme develop mammary tumors. These observations suggest that stromelysin-1 and other matrix metalloproteinases may be useful targets for therapeutic intervention in cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 174-181 |
| Number of pages | 8 |
| Journal | Enzyme and Protein |
| Volume | 49 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
Keywords
- Apoptosis
- Extracellular matrix
- Mammary gland
- Matrix metalloproteinases
- Stromal-epithelial interactions
- Stromelysin-1
ASJC Scopus subject areas
- Biochemistry