The role of stromelysin-1 in stromal-epithelial interactions and cancer

Jane F. Wiesen, Zena Werb

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Stromelysin-1 was one of the first proteinases found to be associated with cancer. In this review we describe the role of stromelysin-1 in normal mammary gland involution. When stromelysin-1 is overexpressed in transgenic mice the mammary gland undergoes precocious involution and is predisposed to forming a reactive stroma resembling that of a wound site or a tumor. Stromelysin-1 may act as an oncogene because transgenic mice expressing an active form of the enzyme develop mammary tumors. These observations suggest that stromelysin-1 and other matrix metalloproteinases may be useful targets for therapeutic intervention in cancer.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalEnzyme and Protein
Volume49
Issue number1-3
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Apoptosis
  • Extracellular matrix
  • Mammary gland
  • Matrix metalloproteinases
  • Stromal-epithelial interactions
  • Stromelysin-1

ASJC Scopus subject areas

  • Biochemistry

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