The role of protein adduction in toxic neuropathies of exogenous and endogenous origin

Peter S. Spencer, Xiao Chen

Research output: Contribution to journalReview articlepeer-review

Abstract

The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.

Original languageEnglish (US)
Article number98
JournalToxics
Volume9
Issue number5
DOIs
StatePublished - May 2021

Keywords

  • Advanced glycation end product
  • Aging
  • Amino acid pyrrolation
  • Central-peripheral distal axonopathy
  • Diabetic neuropathy
  • Protein cross-linking
  • Uremic neuropathy
  • γ-diketone

ASJC Scopus subject areas

  • Toxicology
  • Chemical Health and Safety
  • Health, Toxicology and Mutagenesis

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