The role of prostaglandins in the spontaneous motility of the fallopian tube

M. G. Elder, L. Myatt, G. Chaudhuri

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Spontaneous isometric contractions of the human fallopian tube were measured in vitro. The tubes were obtained during the follicular phase of the menstrual cycle in 16 experiments and during the luteal phase in 23 experiments. The area under the curve and the frequency of spontaneous isometric contractions, together with the amount of prostaglandins E and F produced by the tube, were measured. Using each tissue as its own control, the effects of adding indomethacin or papaverine to the tissue bath were assessed. Indomethacin, a prostaglandin synthetase inhibitor, significantly reduced the prostaglandin output without affecting the tubal motility. By contrast, papaverine, which is a smooth muscle relaxant but not an inhibitor of prostaglandin synthesis, significantly reduced both motility and prostaglandin output. It is concluded that prostaglandins do not have a direct role in the regulation of the spontaneous motility of the human fallopian tube.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalFertility and sterility
Volume28
Issue number1
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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