The Role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma

Patrick K. Ha, Alia Hdeib, David Goldenberg, Heather Jacene, Pavni Patel, Wayne Koch, Joseph Califano, Charles W. Cummings, Paul Flint, Richard Wahl, Ralph P. Tufano

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the role of positron emission tomography and computed tomography (PET-CT) fusion in the management of early-stage and advanced-stage primary head and neck squamous cell cancer. Design: Retrospective analysis, with a blinded evaluation of clinical data and formation of a treatment plan. Setting: Single tertiary academic medical institution. Patients: Thirty-six patients with previously untreated head and neck squamous cell carcinoma who underwent staging CT or magnetic resonance imaging of the neck prior to undergoing PET-CT as part of their initial diagnostic evaluation between July 2000 and January 2005. Main Outcome Measures: Confirmation or alteration of the treatment plan with the addition of the PET-CT information compared with traditional clinical and radiological data alone for early-stage and advanced-stage disease. When available, histopathological results were correlated with the PET-CT findings. Results: Among the 36 patients, PET-CT provided additional information that confirmed the treatment plan in 25 patients (69%) and altered the treatment plan in 11 patients (31%). Six of 11 patients in the altered-treatment group had their tumors upstaged. Four of 8 patients with early-stage tumors had their treatment plan altered, compared with 7 of 28 patients with advanced-stage disease. Among 18 patients who underwent a surgical intervention for their primary tumor, PET-CT identified the primary tumor in all 18 patients and, based on histopathological findings, correctly staged the regional nodal disease in 9 of 16 patients who had their nodal disease addressed. Conclusion: The use of PET-CT is important in the initial treatment planning of early-stage and advanced-stage head and neck squamous cell carcinoma.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume132
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Therapeutics
Neoplasms
Positron Emission Tomography Computed Tomography
Carcinoma, squamous cell of head and neck
Squamous Cell Neoplasms
Head and Neck Neoplasms
Neck
Head
Magnetic Resonance Imaging
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Otorhinolaryngology

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The Role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. / Ha, Patrick K.; Hdeib, Alia; Goldenberg, David; Jacene, Heather; Patel, Pavni; Koch, Wayne; Califano, Joseph; Cummings, Charles W.; Flint, Paul; Wahl, Richard; Tufano, Ralph P.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 132, No. 1, 01.2006, p. 12-16.

Research output: Contribution to journalArticle

Ha, Patrick K. ; Hdeib, Alia ; Goldenberg, David ; Jacene, Heather ; Patel, Pavni ; Koch, Wayne ; Califano, Joseph ; Cummings, Charles W. ; Flint, Paul ; Wahl, Richard ; Tufano, Ralph P. / The Role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. In: Archives of Otolaryngology - Head and Neck Surgery. 2006 ; Vol. 132, No. 1. pp. 12-16.
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abstract = "Objective: To evaluate the role of positron emission tomography and computed tomography (PET-CT) fusion in the management of early-stage and advanced-stage primary head and neck squamous cell cancer. Design: Retrospective analysis, with a blinded evaluation of clinical data and formation of a treatment plan. Setting: Single tertiary academic medical institution. Patients: Thirty-six patients with previously untreated head and neck squamous cell carcinoma who underwent staging CT or magnetic resonance imaging of the neck prior to undergoing PET-CT as part of their initial diagnostic evaluation between July 2000 and January 2005. Main Outcome Measures: Confirmation or alteration of the treatment plan with the addition of the PET-CT information compared with traditional clinical and radiological data alone for early-stage and advanced-stage disease. When available, histopathological results were correlated with the PET-CT findings. Results: Among the 36 patients, PET-CT provided additional information that confirmed the treatment plan in 25 patients (69{\%}) and altered the treatment plan in 11 patients (31{\%}). Six of 11 patients in the altered-treatment group had their tumors upstaged. Four of 8 patients with early-stage tumors had their treatment plan altered, compared with 7 of 28 patients with advanced-stage disease. Among 18 patients who underwent a surgical intervention for their primary tumor, PET-CT identified the primary tumor in all 18 patients and, based on histopathological findings, correctly staged the regional nodal disease in 9 of 16 patients who had their nodal disease addressed. Conclusion: The use of PET-CT is important in the initial treatment planning of early-stage and advanced-stage head and neck squamous cell carcinoma.",
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AU - Patel, Pavni

AU - Koch, Wayne

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