TY - JOUR
T1 - The role of NFκB in healthy and preeclamptic placenta
T2 - Trophoblasts in the spotlight
AU - Armistead, Brooke
AU - Kadam, Leena
AU - Drewlo, Sascha
AU - Kohan-Ghadr, Hamid Reza
N1 - Funding Information:
for production of this article was provided by the Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine at Michigan State University.
Funding Information:
R.K.-G.; writing—original draft preparation, BA.; writing—review and editing, B.A., L.K., H.-R.K.-G., and S.D. and S.D. All authors have agreed to the published version of the manuscript. All authors have agreed to the published version of the manuscript. Funding: Funding for production of this article was provided by the Department of Obstetrics, Gynecology and RFeupnrdoidnugc:t FivuenBdiionlgo gfoyr ipnrtohdeuCctoilolneg oef othf iHs uarmtiacnle Mweads ipcirnoeviadteMdibcyhitghaen DSetaptaertUmneivnet rosfi tOy.bstetrics, Gynecology and Reproductive Biology in the College of Human Medicine at Michigan State University.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention.
AB - The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention.
KW - Nuclear factor kappa-B
KW - Placenta
KW - Preeclampsia
KW - Pregnancy
KW - Trophoblast
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U2 - 10.3390/ijms21051775
DO - 10.3390/ijms21051775
M3 - Review article
C2 - 32150832
AN - SCOPUS:85080989313
SN - 1661-6596
VL - 21
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 5
M1 - 1775
ER -