The role of Langerhans cells in the sexual transmission of HIV

Tatsuyoshi Kawamura, Stephen E. Kurtz, Andrew Blauvelt, Shinji Shimada

    Research output: Contribution to journalArticle

    54 Citations (Scopus)

    Abstract

    Sexual transmission of HIV is the most common mode of infection in the global HIV epidemic. In the absence of an effective vaccine, there is an urgent need for additional strategies to prevent new HIV infections. An emerging body of evidence now indicates that Langerhans cells (LC) are initial cellular targets in the sexual transmission of HIV, and CD4- and CCR5-mediated infection of LC plays a crucial role in virus dissemination. However, interactions between HIV and LC are complex. For example, it is evident that HIV can interact concomitantly with non-LC dendritic cells in two separate and distinct ways: a CD4- and CCR5-dependent infection pathway and a CD4- and CCR5-independent capture pathway mediated by DC-SIGN, a C-type lectin molecule. Thus, there may be multiple ways by which HIV interacts with target cells in the genital mucosa. This review focuses on the recent advances regarding the cellular events that may occur during heterosexual transmission of HIV.

    Original languageEnglish (US)
    Pages (from-to)147-155
    Number of pages9
    JournalJournal of Dermatological Science
    Volume40
    Issue number3
    DOIs
    StatePublished - Dec 2005

    Fingerprint

    Langerhans Cells
    HIV
    C-Type Lectins
    Viruses
    Vaccines
    Infection
    Molecules
    Heterosexuality
    Dendritic Cells
    HIV Infections
    Mucous Membrane

    Keywords

    • Dendritic cell
    • HIV
    • Langerhans cell
    • Sexual transmission

    ASJC Scopus subject areas

    • Dermatology

    Cite this

    The role of Langerhans cells in the sexual transmission of HIV. / Kawamura, Tatsuyoshi; Kurtz, Stephen E.; Blauvelt, Andrew; Shimada, Shinji.

    In: Journal of Dermatological Science, Vol. 40, No. 3, 12.2005, p. 147-155.

    Research output: Contribution to journalArticle

    Kawamura, Tatsuyoshi ; Kurtz, Stephen E. ; Blauvelt, Andrew ; Shimada, Shinji. / The role of Langerhans cells in the sexual transmission of HIV. In: Journal of Dermatological Science. 2005 ; Vol. 40, No. 3. pp. 147-155.
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