The Role of Glucagon-Like Peptide-1 in Energy Homeostasis

Marzieh Salehi, Jonathan Purnell

Research output: Contribution to journalReview article

Abstract

Energy homeostasis is coordinated by bidirectional communication pathways between the brain and peripheral organs, including adipose tissue, muscle, the pancreas, liver, and gut. Disruption of the integrated chemical, hormonal, and neuronal signals that constitute the gut-brain axis significantly contributes to disorders of metabolism and body weight. Initial studies of glucagon-like peptide-1 (GLP-1), a gut hormone released in response to the ingestion of nutrients, focused on its incretin actions to improve postprandial glucose homeostasis by enhancing meal-induced insulin secretion. However, GLP-1 is also a key player in the gut-brain regulatory axis with multiple effects on appetite and energy metabolism outside of its peripheral glucoregulatory actions. In this review, we explore the function of GLP-1 as a component of the gut-brain axis in the regulation of energy homeostasis, and consider the implications of this role for the development of therapeutic treatment options for obesity.

Original languageEnglish (US)
Pages (from-to)183-191
Number of pages9
JournalMetabolic Syndrome and Related Disorders
Volume17
Issue number4
DOIs
StatePublished - May 1 2019

Fingerprint

Glucagon-Like Peptide 1
Homeostasis
Brain
Incretins
Appetite
Energy Metabolism
Meals
Adipose Tissue
Pancreas
Obesity
Eating
Communication
Body Weight
Hormones
Insulin
Glucose
Food
Muscles
Liver
Therapeutics

Keywords

  • appetite
  • energy homeostasis
  • glucagon-like peptide-1 (GLP-1)
  • gut-brain axis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

The Role of Glucagon-Like Peptide-1 in Energy Homeostasis. / Salehi, Marzieh; Purnell, Jonathan.

In: Metabolic Syndrome and Related Disorders, Vol. 17, No. 4, 01.05.2019, p. 183-191.

Research output: Contribution to journalReview article

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