The rise of genomic profiling in ovarian cancer

Rebecca A. Previs, Anil K. Sood, Gordon Mills, Shannon N. Westin

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Introduction: Next-generation sequencing and advances in ‘omics technology have rapidly increased our understanding of the molecular landscape of epithelial ovarian cancers. Areas covered: Once characterized only by histologic appearance and clinical behavior, we now understand many of the molecular phenotypes that underlie the different ovarian cancer subtypes. While the current approach to treatment involves standard cytotoxic therapies after cytoreductive surgery for all ovarian cancers regardless of histologic or molecular characteristics, focus has shifted beyond a ‘one size fits all’ approach to ovarian cancer. Expert commentary: Genomic profiling offers potentially ‘actionable’ opportunities for development of targeted therapies and a more individualized approach to treatment with concomitant improved outcomes and decreased toxicity.

Original languageEnglish (US)
Pages (from-to)1337-1351
Number of pages15
JournalExpert Review of Molecular Diagnostics
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 1 2016
Externally publishedYes

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Keywords

  • Genomic profiling
  • ovarian cancer
  • precision medicine
  • targeted therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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